Molecular structure of α-Sarcin, CAS Number: 86243-64-3
α-Sarcin (CAS 86243-64-3)
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Application:
α-Sarcin is a ribosome-inactivating protein and apoptosis inducer
CAS Number:
86243-64-3
Molecular Weight:
~168000
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
alpha-Sarcin, Aspergillus giganteus is a native alpha-sarcin from Aspergillus giganteus. alpha-Sarcin is a ribosome-inactivating protein that has been demonstrated to induce apoptosis in rhabdomyosarcoma cells. As a specific ribotoxin, it effectively inhibits protein synthesis through the cleavage of 28S RNA. alpha-Sarcin is suitable for induction of apoptosis and inhibition of protein synthesis.
α-Sarcin (CAS 86243-64-3) References
- Cytotoxic mechanism of the ribotoxin alpha-sarcin. Induction of cell death via apoptosis. | Olmo, N., et al. 2001. Eur J Biochem. 268: 2113-23. PMID: 11277935
- Purification of alpha-sarcin and an antifungal protein from mold (Aspergillus giganteus) by chitin affinity chromatography. | Liu, RS., et al. 2002. Protein Expr Purif. 25: 50-8. PMID: 12071698
- Alpha-sarcin catalytic activity is not required for cytotoxicity. | Alford, SC., et al. 2009. BMC Biochem. 10: 9. PMID: 19344516
- Alpha-sarcin cleavage of ribosomal RNA is inhibited by the binding of elongation factor G or thiostrepton to the ribosome. | Miller, SP. and Bodley, JW. 1991. Nucleic Acids Res. 19: 1657-60. PMID: 2027773
- Conditional protein splicing of α-sarcin in live cells. | Alford, SC., et al. 2014. Mol Biosyst. 10: 831-7. PMID: 24481070
- α-sarcin and RNase T1 based immunoconjugates: the role of intracellular trafficking in cytotoxic efficiency. | Tomé-Amat, J., et al. 2015. FEBS J. 282: 673-84. PMID: 25475209
- Involvement of loops 2 and 3 of α-sarcin on its ribotoxic activity. | Castaño-Rodríguez, C., et al. 2015. Toxicon. 96: 1-9. PMID: 25598497
- Effect of alpha-sarcin and ribosome-inactivating proteins on the interaction of elongation factors with ribosomes. | Brigotti, M., et al. 1989. Biochem J. 257: 723-7. PMID: 2930482
- Alpha-sarcin causes a specific cut in 28 S rRNA when microinjected into Xenopus oocytes. | Ackerman, EJ., et al. 1988. J Biol Chem. 263: 17076-83. PMID: 3182833
- The ribonuclease activity of the cytotoxin alpha-sarcin. The characteristics of the enzymatic activity of alpha-sarcin with ribosomes and ribonucleic acids as substrates. | Endo, Y., et al. 1983. J Biol Chem. 258: 2662-7. PMID: 6185500
- Permeability to alpha sarcin in virus-infected cells. | Fernández-Puentes, C. 1983. Mol Cell Biochem. 50: 185-91. PMID: 6304486
- The sarcin/ricin loop, a modular RNA. | Szewczak, AA. and Moore, PB. 1995. J Mol Biol. 247: 81-98. PMID: 7897662
- Translocation of alpha-sarcin across the lipid bilayer of asolectin vesicles. | Oñaderra, M., et al. 1993. Biochem J. 295 (Pt 1): 221-5. PMID: 8216220
Inhibitor of:
9930104L06Rik, CstF-64T, EF-1 ε1, EG666806, GTPBP1, H2-M10.5, POLR3GL, Ribosomal Protein L19, Ribosomal Protein L29, Ribosomal Protein L31, Ribosomal Protein L38, Ribosomal Protein L9, Ribosomal Protein S11, Ribosomal Protein S12, Ribosomal Protein S13, Ribosomal Protein S15, Ribosomal Protein S16, Ribosomal Protein S18, Ribosomal Protein S2, Ribosomal Protein S25, Ribosome (RPL; 40S; 60S), RPL12, RPL14, RPL24, RPL39, RPL39L, RPS4Y1, RPS4Y2, RPUSD4, TIA1, and TINP1.Activator of:
Ribosomal Protein L22, Ribosomal Protein L23, Ribosomal Protein S21, and Ribosomal Protein S29.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-Sarcin, 1 mg | sc-204427 | 1 mg | $316.00 |