PNMA5 Inhibitors
PNMA5 inhibitors are a class of compounds that target the PNMA5 (Paraneoplastic Ma antigen family member 5) protein, a member of the PNMA family. These proteins are typically involved in cellular processes related to neuronal functioning and signaling. Although the exact physiological roles of PNMA5 remain under investigation, it is believed to be involved in regulating various neural pathways and processes, particularly those associated with cell death and immune responses. Inhibition of PNMA5 provides a tool for researchers to investigate its role in cellular pathways, especially within the context of neurological functions and how cells manage stress responses, apoptosis, and potentially aberrant signaling within neural networks.
Inhibitors of PNMA5 are useful in experimental setups where the modulation of this protein can help elucidate its involvement in cell death mechanisms and neuronal signal transduction. By selectively inhibiting PNMA5, researchers can study its downstream effects, including alterations in cellular pathways related to gene expression and apoptosis. Furthermore, PNMA5 inhibitors may shed light on its interaction with other members of the PNMA protein family, providing insight into the broader implications of this class of proteins in cellular regulation. These inhibitors are also valuable in systems biology studies where understanding protein interactions within neural tissues is critical. Through the use of PNMA5 inhibitors, researchers gain a deeper understanding of its role in cellular communication, potentially impacting our knowledge of neural homeostasis and immune interactions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A potent protein kinase inhibitor that by inhibiting kinases could reduce the phosphorylation levels of PNMA5, leading to its functional inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A specific inhibitor of phosphatidylinositol 3-kinase (PI3K), which when inhibited, may prevent the activation of downstream proteins that promote the stability or activity of PNMA5. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
An inhibitor of mitogen-activated protein kinase (MEK), which is involved in the MAPK/ERK pathway; inhibition of this pathway could decrease the activity of downstream proteins including PNMA5. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A PI3K inhibitor, which by dampening the PI3K/Akt pathway could indirectly lead to decreased activity of proteins like PNMA5 that may depend on this pathway for full activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
MEK1/2 inhibitor that can block the MAPK/ERK pathway, potentially reducing the activity or stability of PNMA5 if it is regulated by this pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that could disrupt downstream signaling pathways, potentially leading to decreased activity of proteins such as PNMA5 that may be stabilized or activated by mTOR signaling. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
A ROCK inhibitor, which by inhibiting the RhoA/ROCK pathway might affect the cytoskeletal dynamics and potentially influence the activity or localization of PNMA5. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
An inhibitor of p38 MAP kinase, potentially affecting proteins that are regulated by stress-activated MAPK pathways such as PNMA5, leading to its functional inhibition. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
A JNK inhibitor, which may prevent the phosphorylation and subsequent activation of proteins that might regulate the activity or expression of PNMA5. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
A calcium chelator that by sequestering intracellular calcium could affect calcium-dependent signaling pathways potentially involved in the regulation of PNMA5 activity. | ||||||