Date published: 2025-10-25

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PMEPA1 Inhibitors

PMEPA1 inhibitors belong to a specific chemical class characterized by their ability to selectively target and modulate the activity of PMEPA1, a protein that plays a crucial role in cellular processes. PMEPA1, also known as prostate transmembrane protein, androgen induced 1, is a transmembrane protein that has garnered significant attention due to its involvement in various cellular functions, particularly in the context of signal transduction and molecular pathways.

The inhibitors designed for PMEPA1 exert their effects by binding to specific regions of the protein, thereby interfering with its normal function. This targeted interaction can result in a cascade of molecular events, influencing downstream signaling pathways and cellular responses.PMEPA1 inhibitor class allows for a range of compounds that exhibit unique binding affinities and pharmacokinetic properties. Researchers have been actively exploring the chemical space around PMEPA1 inhibitors to better understand the intricacies of their interaction with the target protein. Structural biology studies, such as X-ray crystallography and NMR spectroscopy, have provided valuable insights into the three-dimensional architecture of the protein-inhibitor complexes, aiding in the rational design of more potent and selective inhibitors.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

MDV3100

915087-33-1sc-364354
sc-364354A
5 mg
50 mg
$240.00
$1030.00
7
(1)

Androgen receptor antagonist that can indirectly inhibit PMEPA1 by blocking the androgen receptor pathway

Bicalutamide

90357-06-5sc-202976
sc-202976A
100 mg
500 mg
$41.00
$143.00
27
(1)

Another androgen receptor antagonist that can indirectly inhibit PMEPA1

Flutamide

13311-84-7sc-204757
sc-204757A
sc-204757D
sc-204757B
sc-204757C
1 g
5 g
25 g
500 g
1 kg
$46.00
$153.00
$168.00
$515.00
$923.00
4
(1)

Androgen receptor antagonist that can inhibit PMEPA1 by blocking its upstream signaling

LY2157299

700874-72-2sc-391123
sc-391123A
5 mg
10 mg
$209.00
$352.00
3
(1)

TGF-beta receptor inhibitor that can inhibit PMEPA1 by blocking TGF-beta signaling

TGF-β RI Kinase Inhibitor V

627536-09-8sc-203294
2 mg
$86.00
3
(1)

TGF-beta receptor inhibitor that can inhibit PMEPA1 indirectly through the TGF-beta pathway

LY2109761

700874-71-1sc-396262
sc-396262A
1 mg
5 mg
$87.00
$270.00
9
(1)

Another TGF-beta receptor inhibitor that can indirectly inhibit PMEPA1

ALK5 Inhibitor II

446859-33-2sc-221234
sc-221234A
sc-221234B
sc-221234C
sc-221234D
sc-221234E
sc-221234F
1 mg
5 mg
10 mg
50 mg
100 mg
500 mg
1 g
$75.00
$150.00
$215.00
$650.00
$1224.00
$4296.00
$7818.00
8
(1)

TGF-beta receptor inhibitor that can inhibit PMEPA1 by blocking its upstream signaling

SB 431542

301836-41-9sc-204265
sc-204265A
sc-204265B
1 mg
10 mg
25 mg
$80.00
$212.00
$408.00
48
(1)

TGF-beta receptor inhibitor that can indirectly inhibit PMEPA1

A 83-01

909910-43-6sc-203791
sc-203791A
10 mg
50 mg
$198.00
$650.00
16
(1)

Inhibitor of the TGF-beta type I receptor ALK5, its effects can indirectly influence the activity of PMEPA1

GW788388

452342-67-5sc-363544
sc-363544A
5 mg
25 mg
$95.00
$384.00
(0)

TGF-beta type I receptor inhibitor, it can indirectly inhibit PMEPA1