PMEPA1 inhibitors belong to a specific chemical class characterized by their ability to selectively target and modulate the activity of PMEPA1, a protein that plays a crucial role in cellular processes. PMEPA1, also known as prostate transmembrane protein, androgen induced 1, is a transmembrane protein that has garnered significant attention due to its involvement in various cellular functions, particularly in the context of signal transduction and molecular pathways.
The inhibitors designed for PMEPA1 exert their effects by binding to specific regions of the protein, thereby interfering with its normal function. This targeted interaction can result in a cascade of molecular events, influencing downstream signaling pathways and cellular responses.PMEPA1 inhibitor class allows for a range of compounds that exhibit unique binding affinities and pharmacokinetic properties. Researchers have been actively exploring the chemical space around PMEPA1 inhibitors to better understand the intricacies of their interaction with the target protein. Structural biology studies, such as X-ray crystallography and NMR spectroscopy, have provided valuable insights into the three-dimensional architecture of the protein-inhibitor complexes, aiding in the rational design of more potent and selective inhibitors.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MDV3100 | 915087-33-1 | sc-364354 sc-364354A | 5 mg 50 mg | $240.00 $1030.00 | 7 | |
Androgen receptor antagonist that can indirectly inhibit PMEPA1 by blocking the androgen receptor pathway | ||||||
Bicalutamide | 90357-06-5 | sc-202976 sc-202976A | 100 mg 500 mg | $41.00 $143.00 | 27 | |
Another androgen receptor antagonist that can indirectly inhibit PMEPA1 | ||||||
Flutamide | 13311-84-7 | sc-204757 sc-204757A sc-204757D sc-204757B sc-204757C | 1 g 5 g 25 g 500 g 1 kg | $46.00 $153.00 $168.00 $515.00 $923.00 | 4 | |
Androgen receptor antagonist that can inhibit PMEPA1 by blocking its upstream signaling | ||||||
LY2157299 | 700874-72-2 | sc-391123 sc-391123A | 5 mg 10 mg | $209.00 $352.00 | 3 | |
TGF-beta receptor inhibitor that can inhibit PMEPA1 by blocking TGF-beta signaling | ||||||
TGF-β RI Kinase Inhibitor V | 627536-09-8 | sc-203294 | 2 mg | $86.00 | 3 | |
TGF-beta receptor inhibitor that can inhibit PMEPA1 indirectly through the TGF-beta pathway | ||||||
LY2109761 | 700874-71-1 | sc-396262 sc-396262A | 1 mg 5 mg | $87.00 $270.00 | 9 | |
Another TGF-beta receptor inhibitor that can indirectly inhibit PMEPA1 | ||||||
ALK5 Inhibitor II | 446859-33-2 | sc-221234 sc-221234A sc-221234B sc-221234C sc-221234D sc-221234E sc-221234F | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 g | $75.00 $150.00 $215.00 $650.00 $1224.00 $4296.00 $7818.00 | 8 | |
TGF-beta receptor inhibitor that can inhibit PMEPA1 by blocking its upstream signaling | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
TGF-beta receptor inhibitor that can indirectly inhibit PMEPA1 | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $198.00 $650.00 | 16 | |
Inhibitor of the TGF-beta type I receptor ALK5, its effects can indirectly influence the activity of PMEPA1 | ||||||
GW788388 | 452342-67-5 | sc-363544 sc-363544A | 5 mg 25 mg | $95.00 $384.00 | ||
TGF-beta type I receptor inhibitor, it can indirectly inhibit PMEPA1 | ||||||