Date published: 2026-4-1

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PLEKHM2 Activators

Plekstrin Homology and RUN Domain Containing M2 (PLEKHM2) Activators represent a chemical class designed to influence the expression or activity of the PLEKHM2 gene. PLEKHM2 is a protein-coding gene with multifaceted roles in various cellular functions, particularly in autophagy, a critical process responsible for the degradation and recycling of damaged cellular components and proteins.

Activators of PLEKHM2 offer a means to modulate the gene's behavior, impacting its involvement in autophagy and other cellular processes. Autophagy is vital for sustaining cellular homeostasis, and any dysregulation in this process can have implications for numerous diseases, including neurodegenerative disorders and cancer. Thus, the exploration of PLEKHM2 and its activators holds significant promise in unraveling the molecular underpinnings of autophagy and its implications for human health and disease. Research into PLEKHM2 Activators falls within the realm of molecular biology and genetics, where scientists delve into the mechanisms governing specific genes and how their expression can be controlled. By elucidating the intricacies of PLEKHM2 regulation and its involvement in autophagy, researchers aim to gain valuable insights into fundamental cellular processes, with implications for understanding and intervening in conditions linked to autophagy dysfunction.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

Retinoic acid regulates gene expression and could influence the expression of genes involved in endosomal transport, like PLEKHM2.

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$78.00
$153.00
$740.00
$1413.00
$2091.00
73
(3)

Forskolin increases cAMP levels, potentially influencing signaling pathways that regulate autophagy and endosomal trafficking.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$43.00
$73.00
$126.00
$243.00
$530.00
$1259.00
11
(1)

EGCG affects cellular metabolism and might influence the expression of proteins involved in autophagy and endosomal transport.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

Curcumin influences various signaling pathways and might affect the expression of proteins like PLEKHM2 involved in cellular stress responses.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

Resveratrol influences cellular stress response pathways, potentially affecting PLEKHM2 expression.

Cholecalciferol

67-97-0sc-205630
sc-205630A
sc-205630B
1 g
5 g
10 g
$71.00
$163.00
$296.00
2
(1)

Vitamin D3 modulates gene expression and might influence the expression of proteins involved in cellular trafficking.

D,L-Sulforaphane

4478-93-7sc-207495A
sc-207495B
sc-207495C
sc-207495
sc-207495E
sc-207495D
5 mg
10 mg
25 mg
1 g
10 g
250 mg
$153.00
$292.00
$489.00
$1325.00
$8465.00
$933.00
22
(1)

Sulforaphane activates Nrf2, a regulator of oxidative stress response, potentially affecting PLEKHM2 expression.

Dexamethasone

50-02-2sc-29059
sc-29059B
sc-29059A
100 mg
1 g
5 g
$91.00
$139.00
$374.00
36
(1)

Dexamethasone, a glucocorticoid, can influence cell differentiation and might affect PLEKHM2 expression.

Lithium

7439-93-2sc-252954
50 g
$214.00
(0)

Lithium influences several signaling pathways and might affect gene expression, potentially including PLEKHM2.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

Rapamycin inhibits mTOR, a key regulator of cell growth and autophagy, and could affect PLEKHM2 expression.