Plekstrin Homology and RUN Domain Containing M2 (PLEKHM2) Activators represent a chemical class designed to influence the expression or activity of the PLEKHM2 gene. PLEKHM2 is a protein-coding gene with multifaceted roles in various cellular functions, particularly in autophagy, a critical process responsible for the degradation and recycling of damaged cellular components and proteins.
Activators of PLEKHM2 offer a means to modulate the gene's behavior, impacting its involvement in autophagy and other cellular processes. Autophagy is vital for sustaining cellular homeostasis, and any dysregulation in this process can have implications for numerous diseases, including neurodegenerative disorders and cancer. Thus, the exploration of PLEKHM2 and its activators holds significant promise in unraveling the molecular underpinnings of autophagy and its implications for human health and disease. Research into PLEKHM2 Activators falls within the realm of molecular biology and genetics, where scientists delve into the mechanisms governing specific genes and how their expression can be controlled. By elucidating the intricacies of PLEKHM2 regulation and its involvement in autophagy, researchers aim to gain valuable insights into fundamental cellular processes, with implications for understanding and intervening in conditions linked to autophagy dysfunction.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid regulates gene expression and could influence the expression of genes involved in endosomal transport, like PLEKHM2. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases cAMP levels, potentially influencing signaling pathways that regulate autophagy and endosomal trafficking. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG affects cellular metabolism and might influence the expression of proteins involved in autophagy and endosomal transport. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin influences various signaling pathways and might affect the expression of proteins like PLEKHM2 involved in cellular stress responses. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol influences cellular stress response pathways, potentially affecting PLEKHM2 expression. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 modulates gene expression and might influence the expression of proteins involved in cellular trafficking. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates Nrf2, a regulator of oxidative stress response, potentially affecting PLEKHM2 expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a glucocorticoid, can influence cell differentiation and might affect PLEKHM2 expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium influences several signaling pathways and might affect gene expression, potentially including PLEKHM2. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a key regulator of cell growth and autophagy, and could affect PLEKHM2 expression. | ||||||