PLEKHM1 Inhibitors
PLEKHM1 inhibitors may contain compounds like Bafilomycin A1, Chloroquine, and Monensin alter the pH gradient across the endosomal membrane, a critical factor for the proper functioning of PLEKHM1 in vesicle fusion events. By modifying the endosomal environment, these chemicals can interfere with the normal trafficking roles of PLEKHM1.
Other chemicals in this class target the cytoskeletal components that facilitate vesicle transport, which is crucial for PLEKHM1-mediated trafficking. Cytochalasin D, ML9, Vinblastine, Paclitaxel, and Nocodazole exert their effects by disrupting actin filaments or microtubules, thereby potentially impeding PLEKHM1's interaction with or movement along these cytoskeletal structures. Furthermore, inhibitors like Dynasore, Wortmannin, and Pitstop 2 interfere with the formation and maturation of vesicles, as well as endocytosis, all of which are essential steps in the pathways where PLEKHM1 operates. Genistein represents a molecule that inhibits tyrosine kinases, which can modulate signaling cascades that may regulate PLEKHM1's function or expression.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Inhibits V-ATPase, which disrupts endosomal acidification and can impair endosome-lysosome fusion, affecting PLEKHM1's endosomal trafficking role. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Ionophore that alters endosomal pH and can disrupt endosomal sorting, potentially impacting PLEKHM1's trafficking functions. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Inhibits dynamin, which is required for endocytic vesicle scission, potentially affecting endosomal trafficking routes involving PLEKHM1. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3 kinase inhibitor that can affect endosomal maturation, potentially disrupting the endosomal-lysosomal pathway where PLEKHM1 is active. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Disrupts actin filaments, potentially affecting vesicle movement and PLEKHM1's role in cytoskeletal-related trafficking. | ||||||
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $110.00 $440.00 $660.00 $1200.00 | 2 | |
Inhibits myosin light chain kinase, which may affect vesicle transport and indirectly impact PLEKHM1-mediated trafficking. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Disrupts microtubules, potentially affecting PLEKHM1's role in microtubule-associated vesicle transport. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Stabilizes microtubules, which can affect vesicle dynamics and possibly influence PLEKHM1's trafficking functions. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Disrupts microtubule polymerization, which can affect microtubule-dependent trafficking, potentially impacting PLEKHM1's function. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Tyrosine kinase inhibitor that can interfere with signaling pathways, potentially affecting PLEKHM1's role in vesicle trafficking. | ||||||