PLEKHG1 Inhibitors
PLEKHG1 Inhibitors refer to a collection of chemicals, most of which are indirectly associated with PLEKHG1's primary function as a guanine nucleotide exchange factor (GEF). The importance of GEFs, such as PLEKHG1, lies in their ability to activate specific small GTPases, and hence, the majority of the compounds in this group target these GTPases or their subsequent signaling pathways. For instance, NSC23766 and EHT 1864 focus on inhibiting Rac1, a GTPase activated by PLEKHG1. Similarly, compounds like ZCL278 and ML141 direct their inhibitory effects towards Cdc42, emphasizing the network of GTPases that PLEKHG1 might interact with.
Further broadening the scope of this category, some chemicals target downstream effectors or related proteins, establishing an intricate web of cellular signaling. IPA-3's inhibition of GTPase PAK1, a known downstream player of Cdc42 and Rac, serves as a prime example. Additionally, while not directly linked to PLEKHG1, inhibitors such as Y16 and Chelerythrine Chloride offer perspectives on possible downstream signaling events or associated pathways. Through this ensemble of chemicals, we gain insights into the multifaceted roles of PLEKHG1 within cellular dynamics and its broader implication in the regulation of small GTPases.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
EHT 1864 | 754240-09-0 | sc-361175 sc-361175A | 10 mg 50 mg | $209.00 $872.00 | 12 | |
Acts as a Rac family small GTPase inhibitor. It binds and locks Rac in its inactive state, impacting any activation by PLEKHG1. | ||||||
SecinH3 | 853625-60-2 | sc-203260 | 5 mg | $273.00 | 6 | |
Inhibits cytohesin GEFs. While it is more specific for cytohesins, its efficacy on PLEKHG1 can be explored. | ||||||
ZCL278 | 587841-73-4 | sc-507369 | 10 mg | $115.00 | ||
A direct Cdc42 GTPase inhibitor. It disrupts the activation of Cdc42, potentially affecting any processes where PLEKHG1 activates Cdc42. | ||||||
ITX 3 | 347323-96-0 | sc-295214 sc-295214A | 10 mg 50 mg | $145.00 $615.00 | ||
This inhibitor targets Trio, a GEF like PLEKHG1, which may provide some insights into PLEKHG1's function. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
A Cdc42 inhibitor. Given the potential role of PLEKHG1 in activating Cdc42, ML141 can counteract its effects. | ||||||
A-967079 | 1170613-55-4 | sc-363348 sc-363348A sc-363348B | 5 mg 25 mg 100 mg | $86.00 $365.00 $924.00 | 5 | |
Inhibitor of JAK2, which plays a role in cytokine signaling. If PLEKHG1 is involved in such pathways, Y16 can alter its downstream effects. | ||||||
CASIN | 425399-05-9 | sc-397016 | 10 mg | $460.00 | 1 | |
Directly targets and inhibits Cdc42, impacting any activation facilitated by PLEKHG1. | ||||||
IPA 3 | 42521-82-4 | sc-204016 sc-204016A | 5 mg 50 mg | $92.00 $449.00 | 6 | |
Targets and inhibits the GTPase PAK1, a downstream effector of Cdc42 and Rac. This can influence PLEKHG1's downstream signaling. | ||||||
GGTI 298 | 1217457-86-7 | sc-361184 sc-361184A | 1 mg 5 mg | $189.00 $822.00 | 2 | |
Targets geranylgeranyl transferase I, an enzyme required for post-translational modification of GTPases. This indirectly affects GTPase activation by PLEKHG1. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
Inhibits PKC, which can be activated downstream of GTPases. By inhibiting PKC, the effects of PLEKHG1 activation can be modulated. | ||||||