PLAGL1 Activators
PLAGL1, the acronym for Pleomorphic Adenoma Gene-Like 1, is a protein that holds a significant place in the intricate network of cellular processes. It is a zinc finger protein and functions as a transcription factor within the cell, which means it has the pivotal role of controlling the rate at which genetic information is transcribed from DNA to mRNA. The gene coding for PLAGL1 is expressed in various tissues across the body and is involved in several key processes, including cell cycle regulation, apoptosis, and differentiation. As a transcription factor, PLAGL1 can bind to specific DNA sequences and either promote or inhibit the transcription of target genes, depending on the context. It is an imprinted gene, which suggests that it plays a role in parent-of-origin-specific gene expression, a crucial aspect of development and metabolism. The expression of PLAGL1 itself is finely tuned by a range of intracellular and extracellular signals, reflecting its involvement in a broad array of physiological pathways.
In the context of cellular biochemistry, certain chemical compounds can act as activators to induce the expression of proteins like PLAGL1. These activators work through diverse mechanisms to stimulate the cellular machinery, leading to an increase in the transcription and subsequent synthesis of PLAGL1. For instance, compounds like 5-Azacytidine act on the epigenetic level, inhibiting enzymes that methylate DNA, which can lead to the activation of gene expression. Other compounds, such as Retinoic acid and Vitamin D3, interact with specific receptors that translocate to the nucleus and bind to DNA response elements, promoting gene transcription. Moreover, molecules like Forskolin and Dibutyryl-cAMP mimic natural cellular messengers and activate signaling pathways that result in the phosphorylation and activation of transcription factors, thereby enhancing the expression of their target genes. Each of these activators operates through a distinct pathway, yet all converge on the common outcome of upregulating the transcription of PLAGL1, highlighting the multifaceted regulation of gene expression within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine acts by inhibiting DNA methyltransferases, leading to the hypomethylation of gene promoters. This hypomethylation can initiate the transcription of previously silenced genes, potentially including the transcriptional activation of PLAGL1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid engages with retinoic acid receptors that bind to DNA at retinoic acid response elements, initiating transcriptional cascades. This interaction can induce the expression of developmental genes, which might encompass the upregulation of PLAGL1. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A specifically inhibits histone deacetylases, resulting in an open chromatin conformation. The less compact chromatin permits greater transcriptional machinery access to DNA, which can stimulate the transcription of genes like PLAGL1. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises intracellular cAMP levels, which in turn activate protein kinase A (PKA). PKA phosphorylates transcription factors that can bind to promoter regions and initiate transcription, potentially leading to the enhanced expression of PLAGL1. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate's inhibition of histone deacetylase creates an acetylated state of histones, which is associated with active transcription. This acetylation can lead to the de-repression of genes, potentially enabling the upregulation of PLAGL1 expression. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
β-Estradiol binds to and activates estrogen receptors, which translocate to the nucleus and bind to estrogen response elements on the DNA, initiating transcription. This activation can specifically upregulate genes responsive to estrogen, such as PLAGL1. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP, a cAMP analog, bypasses membrane receptors and directly stimulates protein kinase A, which can phosphorylate transcription factors and elicit the expression of cAMP-responsive genes, potentially including the expression of PLAGL1. | ||||||
L-3,3′,5-Triiodothyronine, free acid | 6893-02-3 | sc-204035 sc-204035A sc-204035B | 10 mg 100 mg 250 mg | $41.00 $77.00 $153.00 | ||
T3 binds to thyroid hormone receptors that associate with thyroid hormone response elements, triggering transcriptional responses. This engagement can stimulate the expression of thyroid hormone-responsive genes, potentially including the stimulation of PLAGL1. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Cholecalciferol, through its hormonally active form calcitriol, binds to the vitamin D receptor. This complex can then bind to vitamin D response elements, initiating transcriptional events that may include the stimulation of PLAGL1 expression. | ||||||