PL6 Activators
Chemicals that indirectly influence TMEM115 are primarily focused on altering the Golgi apparatus and intracellular trafficking pathways. Brefeldin A and Monensin are well-known for their effects on the Golgi structure and function, which could indirectly impact TMEM115. Nocodazole and Vinblastine disrupt microtubules, integral to intracellular transport, possibly affecting TMEM115-related processes. Golgicide A and Tunicamycin target specific aspects of Golgi function, with potential indirect effects on TMEM115. Forskolin, known for activating adenylate cyclase, might influence vesicle trafficking processes involving TMEM115. Similarly, Wortmannin, an inhibitor of phosphoinositide 3-kinases, could affect pathways involving TMEM115.
Dynasore and Cytochalasin D, which inhibit dynamin and disrupt actin filaments respectively, could indirectly influence TMEM115 through their impact on endocytosis and vesicle movement. Chlorpromazine and Pitstop 2, affecting clathrin-mediated endocytosis, could also indirectly influence TMEM115 function. These compounds do not directly activate TMEM115 but could affect its function by modulating related cellular processes, particularly those associated with the Golgi apparatus and vesicle trafficking. Understanding these interactions is vital for comprehending the broader context of TMEM115's role in cellular organization and trafficking. The mentioned chemicals offer avenues for exploring the indirect modulation of TMEM115, contributing to the understanding of its involvement in essential cellular mechanisms.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Disrupts Golgi structure and function, potentially affecting TMEM115-associated processes. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
An ionophore that alters Golgi apparatus function, possibly influencing TMEM115. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Disrupts microtubules, affecting intracellular trafficking, indirectly influencing TMEM115. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $134.00 $215.00 $440.00 $496.00 | 19 | |
Specifically targets Golgi brefeldin A resistance factor 1, potentially impacting TMEM115. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Inhibits N-linked glycosylation, affecting Golgi function and possibly TMEM115. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, potentially influencing vesicle trafficking and TMEM115. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Inhibitor of phosphoinositide 3-kinases, possibly impacting vesicle trafficking and TMEM115. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Inhibits dynamin, affecting endocytosis and vesicle trafficking, potentially impacting TMEM115. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Disrupts actin filaments, potentially affecting cellular trafficking and indirectly TMEM115. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Alters clathrin-mediated endocytosis, possibly influencing TMEM115 function. | ||||||