PL6 Antibody (38-K): sc-100652

PL6 Antibody (38-K) is a mouse monoclonal IgG1 kappa light chain antibody that detects PL6 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PL6 antibody (38-K) is available as the non-conjugated form. PL6 protein, also known as TMEM115 (transmembrane protein 115) or PP6 (placental protein 6), is a 351 amino acid multi-pass membrane protein predominantly expressed in kidney and skeletal muscle, with lower expression levels found in liver, placenta, pancreas, lung, heart, and brain. PL6 (38-K) monoclonal antibody recognizes a protein structure that includes several transmembrane domains characterized by alpha-helical configurations, which are crucial for stability and functionality within the lipid bilayer. These transmembrane domains facilitate PL6′s role in mediating material exchange and communication between cells and their environment, making PL6 essential for various cellular processes. PL6 contains a phosphoserine residue, indicating potential post-translational modifications that may influence activity and interactions with other proteins. PL6′s ability to form stable hetero- and homodimers further underscores importance in cellular signaling and protein exchange, highlighting relevance in both physiological and pathological contexts.

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PL6 Antibody (38-K) References:

1. Helix-helix packing and interfacial pairwise interactions of residues in membrane proteins.  |  Adamian, L. and Liang, J. 2001. J Mol Biol. 311: 891-907. PMID: 11518538
2. Membrane protein folding: beyond the two stage model.  |  Engelman, DM., et al. 2003. FEBS Lett. 555: 122-5. PMID: 14630331
3. Distinct protein interfaces in transmembrane domains suggest an in vivo folding model.  |  Stevens, TJ., et al. 2004. Protein Sci. 13: 3028-37. PMID: 15498942
4. Enhanced recognition of protein transmembrane domains with prediction-based structural profiles.  |  Cao, B., et al. 2006. Bioinformatics. 22: 303-9. PMID: 16293670
5. Modulation of cell function by small transmembrane proteins modeled on the bovine papillomavirus E5 protein.  |  Freeman-Cook, LL. and Dimaio, D. 2005. Oncogene. 24: 7756-62. PMID: 16299535
6. Membrane protein folding and oligomerization: the two-stage model.  |  Popot, JL. and Engelman, DM. 1990. Biochemistry. 29: 4031-7. PMID: 1694455

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PL6 Antibody (38-K) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PL6 Antibody (38-K) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PL6 Antibody (38-K) Specifications

Alternate Product Name: PL6

Product Clone Name: 38-K

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-352

Epitope Target: PL6

Epitope Species: human

Product Reactivity/Detection: PL6

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PL6 Antibody (38-K): N/A