pki γ Activators
cAMP-dependent protein kinase inhibitor gamma (PKIγ) is a specific inhibitor of the protein kinase A (PKA) holoenzyme, which is a crucial mediator of cAMP signaling in cells. PKIγ belongs to a family of proteins that serve as endogenous regulators of PKA, ensuring that the phosphorylation of substrates by PKA is precisely controlled. By binding to the catalytic subunit of PKA, PKIγ effectively suppresses its activity, which is essential for maintaining cellular signaling fidelity.PKA is involved in a myriad of cellular processes, such as metabolism, memory formation, and cell differentiation. It is activated upon the binding of cAMP, a second messenger produced in response to various extracellular stimuli. PKIγ acts as a guardian of the intracellular cAMP response, preventing unwarranted PKA activity that could otherwise lead to aberrant cellular functions.
The expression and functional role of PKIγ vary among different tissues, reflecting its specialized regulatory roles. It acts as a finely tuned modulator rather than a mere off switch for PKA, contributing to the nuanced regulation of cAMP-dependent signaling pathways. PKIγ ensures that PKA is active only when and where it is needed, preventing excessive activation that could be detrimental to cellular health.Disturbances in PKA regulation, including those involving PKIγ, can have significant implications for human health. PKA dysregulation has been associated with various diseases, including certain forms of cancer and heart disease. As such, PKIγ is a protein of interest; modulating its interaction with PKA could offer a strategy for correcting pathological signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent, broad-spectrum inhibitor of protein kinases, potentially affecting pathways associated with various protein kinases. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is a specific inhibitor of mTOR (mammalian target of rapamycin), a key kinase in regulating cell growth and metabolism. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK (MAPK/ERK kinase), which is part of the MAP kinase pathway, a critical signaling pathway in cells. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of PI3K (phosphoinositide 3-kinase), affecting AKT signaling and various cellular processes. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 specifically inhibits MEK1 and MEK2, affecting the MAPK/ERK pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase, involved in inflammatory responses and stress signaling. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK (c-Jun N-terminal kinases), which are involved in stress signaling and apoptosis. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib, a proteasome inhibitor, can affect various signaling pathways, including those regulated by protein kinases. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Imatinib is a specific inhibitor of certain tyrosine kinases, including BCR-ABL, c-KIT, and PDGF receptors. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
Sorafenib is a kinase inhibitor targeting several receptor tyrosine kinases, particularly in cancer cells. | ||||||