PKA I alpha reg Activators
Items 1 to 10 of 19 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin production and thereby reducing inflammation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, leading to increased production of cAMP. Elevated cAMP levels can bind to the regulatory subunits of PKA (like PKA Iα reg), leading to the release and activation of the catalytic subunits. | ||||||
Ibuprofen | 15687-27-1 | sc-200534 sc-200534A | 1 g 5 g | $53.00 $88.00 | 6 | |
Non-selective COX inhibitor, reduces inflammation, pain, and fever by inhibiting COX enzymes involved in prostaglandin synthesis. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective phosphodiesterase inhibitor. By inhibiting phosphodiesterases, which break down cAMP, IBMX raises intracellular cAMP levels, which can then activate PKA Iα reg. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
This compound is a synthetic, cell-permeable analog of cAMP. It can directly bind to the regulatory subunits of PKA (like PKA Iα reg), promoting activation of the associated catalytic subunits. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Inhibits dihydrofolate reductase, disrupting DNA synthesis in rapidly dividing cells, often used in cancer and autoimmune diseases. | ||||||
Sp-cAMPS | 93602-66-5 | sc-201571 | 1 mg | $97.00 | 3 | |
Similar to 8-Bromo-cAMP, Sp-cAMPS is a cell-permeable cAMP analog that can bind directly to PKA Iα reg and activate the enzyme. | ||||||
Allopurinol | 315-30-0 | sc-207272 | 25 g | $131.00 | ||
Inhibits xanthine oxidase, reducing the production of uric acid and used to treat gout and hyperuricemia. | ||||||
Calcium dibutyryladenosine cyclophosphate | 362-74-3 | sc-482205 | 25 mg | $147.00 | ||
db-cAMP is another cAMP analog that can permeate cell membranes and directly activate PKA Iα reg. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine binds to β-adrenergic receptors on cells, which signal through G-proteins to activate adenylate cyclase. The increased adenylate cyclase activity raises cAMP levels, which in turn activates PKA Iα reg. | ||||||