Pira4 Inhibitors
Pira4 inhibitors encompass a range of chemical compounds that act on distinct cellular signaling pathways to attenuate the functional activity of Pira4. Among these, staurosporine serves as a broad-spectrum kinase inhibitor, targeting the phosphorylation processes essential for Pira4 activation, leading to its subsequent inhibition. Similarly, LY294002 and wortmannin exert their inhibitory effects through the blockade of the PI3K pathway, a crucial upstream regulator of various proteins implicated in Pira4-related signaling networks. The inhibition of PI3K reduces the production of PIP3, thereby impeding the cascade of events that activate Pira4. Compounds such as PD98059 and U0126 hinder the MEK-ERK pathway, with PD98059 specifically preventing ERK1/2 activation, which could indirectly stunt Pira4 activity by disrupting associated signaling mechanisms.
Additional inhibitors, such as rapamycin, target the mTOR complex within the PI3K/AKT/mTOR pathway, leading to a reduction in protein synthesis that indirectly affects Pira4 activity. SB203580, a p38 MAPK inhibitor, and SP600125, a JNK inhibitor, impede their respective MAPK pathways, suggesting a decrease in Pira4's functional activity due to the hampered signaling. PP2 and Y-27632 operate by inhibiting Src family kinases and ROCK, respectively, which could influence Pira4 through phosphorylation events and cytoskeletal dynamics. Finally, Bortezomib disrupts proteasome function, potentially altering the protein turnover of signaling molecules that modulate Pira4, while triciribine specifically targets Akt, diminishing Pira4 regulatory pathways via reduced Akt activity. Collectively, these inhibitors deploy a strategic blockade at critical junctures in cellular signaling networks, ensuring a comprehensive attenuation of Pira4's functional capacity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. By inhibiting these kinases, it impairs the phosphorylation events necessary for the activation of Pira4, leading to its functional inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of PI3K. Inhibition of the PI3K pathway reduces the generation of PIP3, which is necessary for the activation of downstream effectors that might regulate Pira4 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAPK. By inhibiting p38 MAPK, it prevents the activation of downstream targets that could be necessary for Pira4 signaling, thereby indirectly inhibiting Pira4. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that prevents the activation of ERK1/2. As ERK1/2 can be involved in signaling pathways that regulate Pira4, its inhibition can lead to reduced Pira4 activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor that blocks the PI3K/Akt pathway. Decreased Akt activity can lead to diminished regulation of cellular processes that involve Pira4. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which is part of the PI3K/AKT/mTOR signaling pathway. mTOR inhibition can result in decreased protein synthesis and indirectly inhibit Pira4 functionality. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which blocks the ERK1/2 signaling cascade. This suppression can inhibit the signaling pathways modulating Pira4 activity. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an Src family kinase inhibitor. Src kinases can phosphorylate a variety of proteins, including those that regulate Pira4. Inhibition of Src kinases can therefore decrease Pira4 activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which can influence various cellular responses. Inhibition of JNK could disrupt pathways that modulate Pira4, leading to decreased Pira4 activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a selective inhibitor of ROCK, which is involved in cytoskeletal arrangement. Since Pira4 might be regulated by pathways involving the cytoskeleton, ROCK inhibition could reduce Pira4 activity. | ||||||