PIR1 Activators
PIR1 Activators are a distinct class of chemical compounds that specifically enhance the functional activity of PIR1, a phosphatase involved in RNA processing. These activators typically enhance PIR1 activity through specific signaling pathways that PIR1 is directly involved in, such as the cAMP/PKA pathway and PIP2-associated mechanisms. Adenosine, Isoproterenol, Forskolin, IBMX, Rolipram, Dopamine, Epinephrine, Cilostazol, Alprostadil, and H-89 are compounds that enhance the function of PIR1 through the cAMP/PKA pathway. These compounds increase intracellular cAMP levels, leading to the activation of PKA. PKA, a serine/threonine-specific protein kinase, can phosphorylate and activate PIR1. For instance, Forskolin directly activates adenylate cyclase, which increases cAMP levels and subsequently activates PKA. Similarly, Isoproterenol, a beta-adrenergic agonist, and IBMX, a nonspecific inhibitor of phosphodiesterases, also raise cAMP levels, leading to PKA activation and subsequent phosphorylation of PIR1.
PIP2 and U73122 are compounds that enhance PIR1's function through phospholipase C (PLC) and phosphatidylinositol 4,5-bisphosphate (PIP2) related mechanisms. PIP2 itself is a direct activator of PIR1, and increased PIP2 can bind to and enhance the function of PIR1. U73122 is a selective inhibitor of PLC, and its inhibition can increase PIP2 levels. Since PIR1 can interact with PIP2, increased PIP2 levels can enhancePIR1's function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine activates adenosine receptors, leading to an increase in the intracellular cAMP levels. High cAMP levels activate PKA, which can phosphorylate and activate PIR1. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist. It increases cAMP levels, which triggers the activation of PKA. PKA can phosphorylate PIR1, enhancing its activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly activates adenylate cyclase, leading to increased cAMP levels and PKA activation. PKA can phosphorylate and activate PIR1. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, leading to increased cAMP levels and PKA activation. PKA can phosphorylate and activate PIR1. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective phosphodiesterase 4 inhibitor, leading to increased cAMP levels and PKA activation. PKA can phosphorylate and activate PIR1. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine activates D1-like dopamine receptors, leading to an increase in the intracellular cAMP levels. High cAMP levels activate PKA, which can phosphorylate and activate PIR1. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine activates beta-adrenergic receptors, leading to an increase in the intracellular cAMP levels. High cAMP levels activate PKA, which can phosphorylate and activate PIR1. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $109.00 $322.00 | 3 | |
Cilostazol is a phosphodiesterase III inhibitor that raises intracellular cAMP, leading to activation of PKA. Increased PKA activity can phosphorylate PIR1, enhancing its function. | ||||||
PGE1 (Prostaglandin E1) | 745-65-3 | sc-201223 sc-201223A | 1 mg 10 mg | $31.00 $145.00 | 16 | |
Alprostadil activates prostaglandin E receptors, leading to an increase in the intracellular cAMP levels. High cAMP levels activate PKA, which can phosphorylate and activate PIR1. | ||||||