PIR1 Antibody (B-6): sc-393220

PIR1 Antibody (B-6) is a mouse monoclonal IgM kappa antibody that detects PIR1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PIR1 (B-6) antibody is available as the non-conjugated form. PIR1 protein, also known as dual specificity protein phosphatase 11, plays a crucial role in regulating mitogen-activated protein (MAP) kinases, which are essential for various cellular signaling pathways. These pathways are activated by multiple stimuli and mediate significant physiological and pathological changes within cells. Specifically, PIR1 is involved in dephosphorylating critical phosphothreonine and phosphotyrosine residues on MAP kinases, thereby modulating their activity. This regulation ensures proper functioning of cellular responses to growth factors and stress signals, preventing aberrant signaling that could lead to diseases such as cancer. Additionally, PIR1 interacts with splicing factors like 9G8 and SRp30C, suggesting involvement in nuclear mRNA metabolism, which is essential for gene expression and cellular function.

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PIR1 Antibody (B-6) References:

1. Human PIR1 of the protein-tyrosine phosphatase superfamily has RNA 5'-triphosphatase and diphosphatase activities.  |  Deshpande, T., et al. 1999. J Biol Chem. 274: 16590-4. PMID: 10347225
2. Dual specificity phosphatases: a gene family for control of MAP kinase function.  |  Camps, M., et al. 2000. FASEB J. 14: 6-16. PMID: 10627275
3. Role of Pir1 in the construction of the Candida albicans cell wall.  |  Martínez, AI., et al. 2004. Microbiology (Reading). 150: 3151-61. PMID: 15470096
4. An emerging family of dual specificity MAP kinase phosphatases.  |  Keyse, SM. 1995. Biochim Biophys Acta. 1265: 152-60. PMID: 7696343
5. Three yeast genes, PIR1, PIR2 and PIR3, containing internal tandem repeats, are related to each other, and PIR1 and PIR2 are required for tolerance to heat shock.  |  Toh-e, A., et al. 1993. Yeast. 9: 481-94. PMID: 8322511
6. Functional studies of dual-specificity phosphatases.  |  Sun, H. 1998. Methods Mol Biol. 84: 307-18. PMID: 9666459
7. PIR1, a novel phosphatase that exhibits high affinity to RNA. ribonucleoprotein complexes.  |  Yuan, Y., et al. 1998. J Biol Chem. 273: 20347-53. PMID: 9685386

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PIR1 Antibody (B-6) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-PIR1 Antibody (B-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PIR1 Antibody (B-6) Specifications

Alternate Product Name: PIR1

Product Clone Name: B-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 39-58

Epitope Target: PIR1

Epitope Species: human

Product Reactivity/Detection: PIR1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for PIR1 Antibody (B-6): P: Blocking Peptide