PINK1 Activators
PINK1 (PTEN-induced putative kinase 1) plays a critical role in the maintenance and regulation of mitochondrial quality control. Functioning primarily within the mitochondria, PINK1 is pivotal in identifying and marking damaged mitochondria for degradation via mitophagy, a specialized form of autophagy. This process is crucial for cellular health, as it ensures the removal of dysfunctional mitochondria, thereby preventing potential harm from mitochondrial dysfunction, such as increased oxidative stress or impaired ATP production. The activation of PINK1 is intricately linked to the mitochondrial membrane potential; under normal conditions, PINK1 is rapidly imported into mitochondria and degraded. However, upon mitochondrial damage, PINK1 stabilizes on the outer mitochondrial membrane, where it can recruit and phosphorylate Parkin, a ubiquitin ligase, thereby marking the damaged mitochondria for degradation. This protective mechanism underscores the importance of PINK1 in cellular resilience and energy homeostasis.
The activation of PINK1 and its downstream effects are integral to the preservation of mitochondrial health and function. The indirect activators listed, while not directly interacting with PINK1, support mitochondrial health, enhance resistance to oxidative stress, and promote mitochondrial dynamics and quality control-all of which are conducive to the optimal functioning of PINK1. By maintaining a healthy mitochondrial network, these chemicals indirectly facilitate the conditions necessary for PINK1 activation and function. It's important to note that while these activators do not directly bind or modulate PINK1 activity, their effects on mitochondrial health and stress responses can indirectly promote the activation of PINK1 pathways, highlighting the interconnected nature of cellular and mitochondrial health mechanisms. This underscores the potential of targeting mitochondrial health and function as a strategy to indirectly support the activation and role of PINK1 in mitochondrial maintenance and protection against cellular stress.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $70.00 $180.00 | 1 | |
Coenzyme Q10 enhances mitochondrial function and is crucial for ATP production. By supporting mitochondrial function, Coenzyme Q10 indirectly supports the activation of PINK1 by maintaining mitochondrial health and integrity, which is essential for PINK1 to exert its protective roles in mitochondria. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+ is essential for cellular energy metabolism and mitochondrial function. It promotes the activation of PINK1 by enhancing mitochondrial quality control mechanisms. Increased NAD+ levels support mitochondrial health, indirectly facilitating PINK1 activation and its role in mitochondrial maintenance. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol promotes mitochondrial biogenesis and function through SIRT1 activation. This indirect effect enhances mitochondrial quality and health, providing an optimal environment for PINK1 activation and its subsequent roles in mitochondrial maintenance. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
Alpha-Lipoic Acid supports mitochondrial metabolism and reduces oxidative stress, indirectly facilitating PINK1 activation. This antioxidant aids in maintaining mitochondrial health, necessary for PINK1's protective actions. | ||||||
Creatine, anhydrous | 57-00-1 | sc-214774 sc-214774A | 10 mg 50 g | $27.00 $77.00 | 2 | |
Creatine enhances mitochondrial energetics, indirectly supporting PINK1 activation. By improving energy supply, it aids in maintaining mitochondrial function and health, where PINK1 plays a critical role. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, through its anti-inflammatory and antioxidant properties, supports mitochondrial health, indirectly facilitating the activation of PINK1. It aids in maintaining an optimal mitochondrial environment for PINK1's role in cellular homeostasis. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine promotes autophagy and mitochondrial health, indirectly supporting PINK1 activation. Through enhancing cellular recycling processes, it contributes to the maintenance of mitochondrial quality, essential for PINK1 function. | ||||||
Ursolic Acid | 77-52-1 | sc-200383 sc-200383A | 50 mg 250 mg | $55.00 $176.00 | 8 | |
Ursolic Acid supports mitochondrial health and function through its anti-inflammatory and antioxidant effects, indirectly promoting PINK1 activation. It aids in preserving the mitochondrial environment necessary for PINK1's protective roles. | ||||||
Carnosine | 305-84-0 | sc-202521A sc-202521 | 100 mg 1 g | $20.00 $43.00 | 1 | |
Carnosine exhibits antioxidant properties that support mitochondrial integrity, indirectly facilitating PINK1 activation. By maintaining mitochondrial health, it supports the environment necessary for the optimal function of PINK1. | ||||||