Carnosine (CAS 305-84-0)
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Carnosine is a dipeptide compound that functions as a antioxidant in biological systems. It acts by scavenging free radicals and reactive oxygen species, thereby protecting cells and tissues from oxidative damage. Carnosine also plays a role in buffering intracellular pH, helping to maintain the acid-base balance within cells. At the molecular level, carnosine interacts with metal ions, such as copper and zinc, forming stable complexes that can mitigate oxidative stress. Carnosine inhibit the formation of advanced glycation end products (AGEs). Its mechanism of action involves binding to proteins and reducing the formation of these harmful compounds. Carnosine serves as a multifunctional molecule in cellular defense, contributing to the maintenance of cellular homeostasis and protection against oxidative damage.
Carnosine (CAS 305-84-0) References
- Metabolic transformation of neuropeptide carnosine modifies its biological activity. | Boldyrev, A. and Abe, H. 1999. Cell Mol Neurobiol. 19: 163-75. PMID: 10079975
- Carnosine as a regulator of soluble guanylate cyclase. | Severina, IS., et al. 2000. Biochemistry (Mosc). 65: 783-8. PMID: 10951096
- Carnosine reacts with protein carbonyl groups: another possible role for the anti-ageing peptide? | Hipkiss, AR. and Brownson, C. 2000. Biogerontology. 1: 217-23. PMID: 11707898
- Carnosine and homocarnosine, the forgotten, enigmatic peptides of the brain. | Bauer, K. 2005. Neurochem Res. 30: 1339-45. PMID: 16341596
- Carnosine and its possible roles in nutrition and health. | Hipkiss, AR. 2009. Adv Food Nutr Res. 57: 87-154. PMID: 19595386
- Physiology and pathophysiology of carnosine. | Boldyrev, AA., et al. 2013. Physiol Rev. 93: 1803-45. PMID: 24137022
- Systematic review and stratified meta-analysis of the efficacy of carnosine in animal models of ischemic stroke. | Davis, CK., et al. 2016. J Cereb Blood Flow Metab. 36: 1686-1694. PMID: 27401803
- Carnosine and advanced glycation end products: a systematic review. | Ghodsi, R. and Kheirouri, S. 2018. Amino Acids. 50: 1177-1186. PMID: 29858687
- Understanding the antioxidant and carbonyl sequestering activity of carnosine: direct and indirect mechanisms. | Aldini, G., et al. 2021. Free Radic Res. 55: 321-330. PMID: 33302741
- Anti-cancer actions of carnosine and the restoration of normal cellular homeostasis. | Turner, MD., et al. 2021. Biochim Biophys Acta Mol Cell Res. 1868: 119117. PMID: 34384791
- Carnosine Improves Cognitive Impairment Through Promoting SIRT6 Expression and Inhibiting Endoplasmic Reticulum Stress in a Diabetic Encephalopathy Model. | Peng, D., et al. 2022. Rejuvenation Res. 25: 79-88. PMID: 35302398
- Unveiling the Hidden Therapeutic Potential of Carnosine, a Molecule with a Multimodal Mechanism of Action: A Position Paper. | Caruso, G. 2022. Molecules. 27: PMID: 35630780
- Carnosine as a potential therapeutic for the management of peripheral vascular disease. | Feehan, J., et al. 2022. Nutr Metab Cardiovasc Dis. 32: 2289-2296. PMID: 35973888
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Carnosine, 100 mg | sc-202521A | 100 mg | $20.00 | |||
Carnosine, 1 g | sc-202521 | 1 g | $43.00 |