PICOT Activators
PICOT Activators are a diverse group of chemical compounds that indirectly enhance the functional activity of PICOT through various signaling pathways. Forskolin, by elevating cAMP levels, indirectly enhances PICOT's activity in regulating protein phosphatase 2A (PP2A). Similarly, the kinase inhibitor (-)-Epigallocatechin Gallate can indirectly augment PICOT's functional role by shifting signaling balance in favor of pathways where PICOT is active. D-erythro-Sphingosine-1-phosphate, through its lipid signaling mechanisms, and okadaic acid, a PP2A inhibitor, both enhance PICOT's regulatory roles by influencing the pathways it modulates. Calyculin A, another PP2A inhibitor, and PMA, which activates PKC, contribute to the enhancement of PICOT's activity in the signaling pathways they influence. The PI3K inhibitor LY 294002 and the broad-spectrum kinase inhibitor staurosporine might augment PICOT's functional role by shifting the signaling equilibrium or by lifting inhibition on pathways where PICOT is active.
The functional activity of PICOT is further influenced by compounds like U0126 and SB 203580, which inhibit MEK and p38 MAPK, respectively. These inhibitors may enhance PICOT's activity by altering the MAPK/ERK and p38 MAPK pathways, which could intersect with PICOT's regulatory functions. Rapamycin, as an mTOR inhibitor, and A23187, a calcium ionophore, also play roles in modulating signaling pathways that intersect with those regulated by PICOT. These compounds, through their targeted effects on cellular signaling, collectively facilitate the enhancement of PICOT's functions without necessitating direct activation or upregulation of its expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels. This elevation in cAMP activates PKA, which phosphorylates various proteins, potentially influencing the pathways where PICOT is involved. PICOT's functional activity is augmented as it interacts with these pathways, particularly in its role in modulating protein phosphatase 2A (PP2A). | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
(-)-Epigallocatechin Gallate, a kinase inhibitor, impacts pathways involving protein kinases like PKA and PKC. By inhibiting competitive kinases, (-)-Epigallocatechin Gallate can shift signaling balance, favoring pathways where PICOT is active, enhancing its role in PP2A modulation. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
This lipid signaling molecule activates G protein-coupled receptors, influencing pathways that intersect with those regulated by PICOT. This interaction can lead to an enhancement of PICOT's activity in its regulatory role over PP2A. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
As a potent inhibitor of PP2A, okadaic acid indirectly enhances PICOT's function by increasing the need for PICOT's regulatory role in counterbalancing PP2A activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Similar to okadaic acid, Calyculin A inhibits PP2A. This inhibition indirectly boosts PICOT's functional role in PP2A regulation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in numerous signaling pathways that could intersect with PICOT’s regulatory roles, potentially enhancing its activity in these pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
As a PI3K inhibitor, LY 294002 alters signaling pathways that may intersect with PICOT’s functional role, particularly in pathways where PI3K activity impacts PP2A regulation. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
This broad-spectrum protein kinase inhibitor might selectively enhance PICOT's pathways by inhibiting kinases that negatively regulate the pathways where PICOT is active. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
This ionophore increases intracellular calcium levels, which can activate calcium-dependent signaling pathways potentially interacting with PICOT’s regulatory roles. | ||||||