PHF13 Activators
PHF13 Activators comprises a group of compounds that have the to influence the activity of the PHF13 protein by targeting various cellular pathways associated with chromatin regulation and gene expression. These activators include valproic acid, decitabine, alpha-amanitin, etoposide, and doxorubicin, each operating through distinct mechanisms.
TSA and valproic acid result in increased histone acetylation and a more open chromatin structure. This modulation of chromatin structure can affect PHF13 Additionally, 5-azacytidine and decitabine lead to reduced DNA methylation patterns. Alpha-amanitin inhibits RNA Polymerase II, disrupting transcription processes. PHF13 is associated with transcriptional regulation, alpha-amanitin-induced inhibition of RNA Polymerase II can impact its activity. Furthermore, etoposide and doxorubicin induce DNA damage, which can activate DNA damage response pathways. PHF13 is connected to DNA repair or damage response pathways, these agents may indirectly influence its function by triggering DNA damage responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid is an HDAC inhibitor, similar to TSA, enhancing histone acetylation, which may influence PHF13 if it plays a role in epigenetic regulation. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine is another DNMT inhibitor that modulates DNA methylation, potentially impacting PHF13 if it plays a role in epigenetic control of gene expression. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
Alpha-amanitin is an RNA Polymerase II inhibitor, disrupting transcription and potentially influencing PHF13 if it is involved in transcriptional regulation. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide induces DNA damage, which may indirectly affect PHF13 if it is connected to DNA repair or damage response pathways. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin is another DNA-damaging agent, inducing DNA damage responses that can potentially influence PHF13 if it is linked to DNA repair pathways. | ||||||