PHF13 Inhibitors
PHF13 inhibitors constitute a diverse group of chemical compounds that modulate the protein's function indirectly by altering the chromatin landscape. These compounds primarily target enzymes involved in the addition or removal of post-translPHF13 inhibitors constitute a diverse group of chemical compounds that modulate the protein's function indirectly by altering the chromatin landscape. These compounds primarily target enzymes involved in the addition or removal of post-translational modifications (PTMs) on histones, such as acetylation and methylation. For instance, Trichostatin A and MS-275 inhibit histone deacetylases, leading to a more relaxed chromatin state that can impair the role of PHF13 in transcriptional regulation. On the other hand, 5-Azacytidine and RG108 inhibit DNA methyltransferases, inducing changes in gene expression that could counteract the function of PHF13.
Similarly, other PHF13 inhibitors affect the function of this protein by targeting histone methyltransferases or proteins that recognize histone modifications. BIX-01294, UNC0638, GSK126, EPZ-5676, and Chaetocin inhibit different histone methyltransferases, leading to alterations in the methylation status of histones that could impact PHF13's chromatin-binding properties. JQ1 and I-BET151, which inhibit bromodomain-containing proteins, and YF2, an inhibitor of the histone demethylase LSD1, can also affect the function of PHF13 by altering the epigenetic landscape.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a potent and selective inhibitor of histone deacetylases (HDACs). These enzymes are responsible for the deacetylation of histones, which can lead to chromatin condensation and transcriptional repression. PHF13 is a chromatin-associated protein, and its function can be indirectly inhibited when HDACs are blocked, leading to a more relaxed chromatin state and altered gene expression profiles. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a cytidine analog that inhibits DNA methyltransferases, leading to DNA hypomethylation. This alteration in the DNA methylation landscape can indirectly inhibit PHF13 by promoting changes in gene expression that can counteract the function of PHF13 in transcriptional regulation. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 is a small molecule that inhibits the bromodomain-containing proteins BRD2, BRD3, and BRD4. These proteins recognize and bind acetylated histones, influencing gene expression. By inhibiting these proteins, JQ1 can indirectly affect PHF13, as it also binds to acetylated histones, thereby potentially altering its function. | ||||||
UNC0638 | 1255580-76-7 | sc-397012 | 10 mg | $315.00 | ||
UNC0638 is a potent and selective inhibitor of G9a and GLP histone methyltransferases. These enzymes methylate histone H3 at lysine 9 (H3K9), a mark often associated with gene silencing. Inhibiting these enzymes can indirectly impact PHF13, as its binding to histones could be affected by changes in histone methylation. | ||||||
9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-β-D-ribofuranosyl]-9H-purin-6-amine | 1380288-87-8 | sc-500607 | 50 mg | $13500.00 | ||
EPZ-5676 is a potent and selective inhibitor of DOT1L methyltransferase, which specifically methylates histone H3 at lysine 79 (H3K79). Changes in H3K79 methylation can indirectly inhibit PHF13 by altering its chromatin-binding properties. | ||||||
GSK126 | 1346574-57-9 | sc-490133 sc-490133A sc-490133B | 1 mg 5 mg 10 mg | $92.00 $243.00 $306.00 | ||
GSK126 is a potent and selective inhibitor of EZH2 methyltransferase, which specifically methylates histone H3 at lysine 27 (H3K27). Changes in H3K27 methylation can indirectly inhibit PHF13 by altering its chromatin-binding properties. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
I-BET151 is a small molecule that inhibits the bromodomain-containing proteins BRD2, BRD3, BRD4, and BRDT. These proteins recognize and bind acetylated histones, influencing gene expression. By inhibiting these proteins, I-BET151 can indirectly affect PHF13, as it also binds to acetylated histones, thereby potentially altering its function. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108 is a non-nucleoside inhibitor of DNA methyltransferases. It prevents DNA methylation, leading to changes in the gene expression landscape that can indirectly inhibit PHF13 by counteracting its function in transcriptional regulation. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
MS-275 is a potent HDAC inhibitor, specifically targeting HDAC1. By inhibiting HDAC1, this compound alters the acetylation status of histones, potentially affecting PHF13's function in the regulation of chromatin structure and gene expression. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $37.00 $112.00 $408.00 | ||
BIX-01294 is a specific inhibitor of G9a histone methyltransferase. By inhibiting G9a, this compound indirectly affects PHF13 by altering the methylation status of histones, which can impact PHF13's chromatin-binding properties. | ||||||