PHACTR4 Inhibitors
Chemical inhibitors of PHACTR4 can exert their inhibitory effects through various mechanisms that impinge upon the cytoskeletal dynamics PHACTR4 is known to regulate. The ROCK inhibitors Y-27632 and H-1152P can inhibit PHACTR4 by preventing the phosphorylation of downstream targets involved in actin cytoskeleton organization, leading to decreased stress fiber formation and, consequently, an inhibition of PHACTR4's role in actin regulation. Similarly, the myosin II ATPase activity inhibitor Blebbistatin and the MLCK inhibitor ML-7 can suppress actin-myosin contraction, which is a process that PHACTR4 could regulate. By stabilizing actin filaments in a relaxed state, these compounds can indirectly inhibit the effects of PHACTR4 on the cytoskeleton. Furthermore, Latrunculin A and Cytochalasin D, by binding to actin monomers and disrupting actin polymerization, can inhibit PHACTR4's ability to interact with and stabilize actin filaments.
Additionally, the Arp2/3 complex, which is targeted by CK-636, is essential for the nucleation of new actin filaments, and its inhibition can therefore disrupt the actin network formation that PHACTR4 might influence. SMIFH2, by inhibiting formin-dependent actin nucleation and elongation, can also reduce the formation of actin structures that are potential targets of PHACTR4 regulation. Jasplakinolide, through its actin filament stabilization, can disrupt the dynamic regulation of the cytoskeleton by PHACTR4. Finally, the PKC inhibitor Chelerythrine can influence the actin cytoskeleton organization as well, and thereby indirectly inhibit any regulatory effects PHACTR4 might have on this system.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of ROCK (Rho-associated protein kinase), which is implicated in actin cytoskeleton organization. PHACTR4 has been associated with cytoskeletal regulation. Inhibition of ROCK by Y-27632 can lead to cytoskeleton relaxation and therefore inhibit PHACTR4's ability to influence cytoskeletal dynamics. | ||||||
H-1152 dihydrochloride | 451462-58-1 | sc-203592 sc-203592A | 1 mg 5 mg | $104.00 $364.00 | 7 | |
H-1152P is another potent inhibitor of ROCK. Given PHACTR4's role in actin filament organization and its interaction with RhoA/ROCK signaling, H-1152P can inhibit the ROCK pathway, potentially reducing the ability of PHACTR4 to modulate actin cytoskeleton structures. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA (sarcoplasmic/endoplasmic reticulum Ca2+ ATPase) pump inhibitor, leading to increased cytosolic calcium levels. Since PHACTR4 is known to interact with the actin cytoskeleton, which can be affected by calcium levels, Thapsigargin's action can result in a dysregulated actin cytoskeleton, thus inhibiting PHACTR4's normal function. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Blebbistatin is an inhibitor of myosin II ATPase activity. As PHACTR4 is involved in actin filament organization, Blebbistatin's inhibition of myosin II can prevent proper actin-myosin interactions, thereby inhibiting the role of PHACTR4 in actin cytoskeleton dynamics. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 is an inhibitor of myosin light chain kinase (MLCK), which phosphorylates the myosin light chain, leading to actin-myosin contraction. Because PHACTR4 is implicated in actin regulation, inhibition of MLCK by ML-7 can indirectly inhibit PHACTR4 by stabilizing the actin cytoskeleton in a relaxed state. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
W-7 is a calmodulin antagonist that interferes with calcium signaling. PHACTR4, being associated with cytoskeletal regulation, may be influenced by calcium-calmodulin-dependent pathways. Inhibition of calmodulin by W-7 can lead to the inhibition of calcium-mediated regulatory processes involving PHACTR4. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A disrupts actin polymerization by binding to actin monomers. PHACTR4's activity in the regulation of actin cytoskeleton can be inhibited by Latrunculin A as it prevents the formation of actin filaments that PHACTR4 might regulate. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D is an inhibitor of actin polymerization and induces depolymerization of actin filaments. By disrupting actin filaments, it can inhibit the functions of PHACTR4 that are related to actin filament organization and stability. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
SMIFH2 is a formin inhibitor that impedes actin nucleation and elongation. As PHACTR4 is involved in actin dynamics, inhibition of formin by SMIFH2 can lead to a decrease in actin filament formation, thereby inhibiting PHACTR4's interaction with the actin cytoskeleton. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide stabilizes actin filaments and can result in actin aggregation. This stabilization can inhibit PHACTR4's normal function, as PHACTR4 may require dynamic actin filament turnover to exert its regulatory effects on the cytoskeleton. | ||||||