PHACTR4 Activators
PHACTR4 Activators are a collection of chemical entities that, through distinct mechanisms, enhance the functional activity of PHACTR4. Forskolin, for instance, elevates intracellular cAMP levels and activates protein kinase A (PKA), which may lead to the phosphorylation of targets within the actin filament organization process, a pathway where PHACTR4 is involved. This phosphorylation cascade can enhance PHACTR4's function in cytoskeletal regulation and cell motility. Similarly, IBMX, by inhibiting phosphodiesterase activity, prevents cAMP and cGMP breakdown, presumably bolstering PHACTR4 activity through the cAMP/PKA signaling axis. Epigallocatechin gallate modulates kinase activity and may tune the phosphorylation state within PHACTR4-associated pathways, impacting actin assembly and cell adhesion, while PMA activates PKC, which could lead to downstream signaling changes that amplify PHACTR4's role in cytoskeleton regulation.
In addition to these, LY294002's inhibition of PI3K might adjust phosphorylation states in pathways engaging PHACTR4, potentially enhancing its involvement in cytoskeletal organization. FTY720 and Sphingosine-1-phosphate both engage S1P receptors, which are integral to pathways governing cytoskeletal dynamics, potentially activating PHACTR4's function in these processes. U0126, by modulating the MAPK pathway, Calyculin A, and Okadaic Acid, through inhibition of protein phosphatases, may hyperphosphorylate proteins within actin dynamics regulation, indirectly boosting PHACTR4's role.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels, which in turn activates PKA (protein kinase A). PKA phosphorylates target proteins, potentially enhancing the activity of PHACTR4 in its role in actin filament organization and cell motility. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which prevents the degradation of cAMP and cGMP, leading to their accumulation. Elevated levels of these cyclic nucleotides may enhance PHACTR4 activity related to cAMP/PKA signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
This polyphenol acts as an antioxidant and also modulates kinase activity. It may bolster PHACTR4 activity by modifying the phosphorylation state of proteins within signaling pathways that PHACTR4 is a part of, thereby impacting actin filament assembly and cell adhesion. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is an activator of protein kinase C (PKC) which is involved in various signal transduction pathways. Activation of PKC may lead to downstream effects that enhance the activity of PHACTR4 in the regulation of the cytoskeleton and related cellular processes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of PI3K, which may lead to altered phosphorylation cascades affecting actin dynamics. The inhibition of PI3K can modulate pathways where PHACTR4 is a component, potentially enhancing PHACTR4’s role in cytoskeletal organization. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
FTY720 is phosphorylated in vivo to form a sphingosine-1-phosphate analog, modulating S1P receptors and potentially influencing actin cytoskeleton dynamics. This may indirectly activate PHACTR4 by affecting signaling pathways that govern cytoskeletal rearrangement. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
This lipid signaling molecule can activate S1P receptors, which are part of pathways that regulate cytoskeletal rearrangement and cell migration. S1P receptor activation may indirectly enhance PHACTR4 activity that is implicated in such cellular processes. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is an inhibitor of protein phosphatases 1 and 2A, which could result in the hyperphosphorylation of cellular proteins. This may indirectly enhance PHACTR4 activity by altering the phosphorylation state of components within the actin cytoskeleton regulatory network. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Similar to Calyculin A, Okadaic Acid is a potent inhibitor of protein phosphatases. Its action could lead to an enhanced phosphorylation state of proteins within pathways that include PHACTR4, potentially increasing PHACTR4's activity related to actin filament regulation. | ||||||