PET100 Inhibitors
The array of chemicals known as PET100 Inhibitors centers on their ability to interfere with the cytochrome c oxidase (COX) system. COX, a significant enzyme in the mitochondrial electron transport chain, works hand in hand with PET100 for its biogenesis. Inhibitors like Antimycin A, Azide, and Cyanide disturb COX's function by acting on its components or the electron transport chain, thereby potentially influencing PET100's role. For instance, compounds such as Myxothiazol and Stigmatellin specifically bind to sites on cytochrome b, impacting the electron transport chain's function. This disturbance can ripple to PET100 due to its intimate relationship with COX assembly. Thenoyltrifluoroacetone (TTFA) and Rotenone, which inhibit specific sites in the electron transport chain, highlight the myriad of ways PET100 can be indirectly influenced. A shared characteristic among these chemicals is their ability to hinder the electron transport process in mitochondria, emphasizing the interconnected nature of mitochondrial proteins and processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $55.00 $63.00 $1675.00 $4692.00 | 51 | |
Inhibits cytochrome c reductase, affecting the electron transport chain and potentially COX assembly. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $43.00 $155.00 $393.00 $862.00 $90.00 | 8 | |
Binds to the heme a3 of COX, inhibiting its activity and potentially influencing PET100 function. | ||||||
Myxothiazol | 76706-55-3 | sc-507550 | 1 mg | $148.00 | ||
Binds to the Qo site of cytochrome bc1, affecting the electron transport chain, which can indirectly impact PET100 function. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $149.00 $12495.00 | 18 | |
Inhibits ATP synthase, causing reduced electron transport and potentially affecting COX assembly and PET100 function. | ||||||
Nonyl-4-hydroxyquinoline-N-oxide | 316-66-5 | sc-501004 | 10 mg | $622.00 | ||
Inhibits cytochrome b in the electron transport chain, potentially impacting PET100 indirectly. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $37.00 | 1 | |
Inhibits the succinate-ubiquinone reductase site, potentially affecting COX and indirectly PET100. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Inhibits complex I of the electron transport chain, which can potentially affect PET100 indirectly. | ||||||
Piericidin A | 2738-64-9 | sc-202287 | 2 mg | $291.00 | 24 | |
Inhibits complex I, potentially affecting the downstream PET100 function | ||||||