Periostin Inhibitors
Periostin inhibitors constitute a distinct chemical class recognized for their capacity to modulate the activity of Periostin, an extracellular matrix protein involved in various physiological processes. These inhibitors function by interfering with the interactions involving Periostin, which plays a critical role in tissue development, wound healing, and cellular responses. Periostin is known to contribute to cell adhesion, migration, and tissue remodeling, facilitating dynamic cellular behaviors in response to environmental cues. Periostin inhibitors are carefully designed to target specific binding sites or molecular pathways associated with Periostin, thus influencing its cellular functions and downstream effects.
The development of Periostin inhibitors entails a comprehensive understanding of the structural attributes of Periostin and its interactions with cells and other extracellular components. Researchers in this field work to engineer molecules with high selectivity and affinity for Periostin, enabling precise modulation of its activities. These inhibitors often incorporate innovative design strategies that disrupt key molecular interactions necessary for Periostin's functional role in tissue dynamics and cellular responses. By gaining insights into the intricate mechanisms through which Periostin participates in tissue remodeling and cellular behavior modulation, researchers aim to unravel its significance in fundamental biological phenomena. The ongoing advancements in molecular pharmacology and chemical synthesis drive the refinement of Periostin inhibitors, offering applications across diverse scientific domains where manipulation of Periostin-mediated processes is of interest.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $57.00 | 1 | |
Hydroxychloroquine is an autophagy inhibitor that can down-regulate the expression of extracellular matrix proteins including periostin by inhibiting lysosomal activity in fibroblasts. This reduction in ECM protein expression can lead to decreased fibrosis. | ||||||
Pirfenidone | 53179-13-8 | sc-203663 sc-203663A | 10 mg 50 mg | $102.00 $416.00 | 6 | |
Pirfenidone modulates TGF-β activity, a key regulator of periostin expression. By diminishing TGF-β signaling, pirfenidone can indirectly reduce periostin levels, thereby impacting fibrosis and tissue remodeling. | ||||||
Cilengitide | 188968-51-6 | sc-507335 | 5 mg | $215.00 | ||
An integrin antagonist that has been investigated for its potential to inhibit angiogenesis and tumor growth. Periostin is involved in various processes, including angiogenesis and tissue remodeling. | ||||||
Tranilast | 53902-12-8 | sc-200389 sc-200389A sc-200389B sc-200389C | 10 mg 50 mg 1 g 5 g | $31.00 $103.00 $283.00 $978.00 | 2 | |
Tranilast attenuates TGF-β signaling, which is crucial for periostin expression. It indirectly suppresses periostin by reducing fibroblast activation and ECM deposition, thus affecting fibrosis. | ||||||
Halofuginone | 55837-20-2 | sc-507290 | 100 mg | $1775.00 | ||
Halofuginone inhibits Smad3 phosphorylation, a downstream effect of TGF-β signaling and a regulator of periostin expression. This action can lead to reduced fibrosis by indirectly lowering periostin levels. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor that indirectly affects periostin expression by modulating AP-1 activity, which is involved in the transcriptional regulation of ECM components, including periostin. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580, a p38 MAPK inhibitor, can influence periostin expression indirectly by altering cytokine production and inflammation, both of which are involved in periostin-mediated pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002, a PI3K inhibitor, can down-regulate periostin expression indirectly by affecting AKT signaling, which is involved in cell survival, proliferation, and ECM production. | ||||||
GW 9662 | 22978-25-2 | sc-202641 | 5 mg | $70.00 | 30 | |
GW9662, a PPARγ antagonist, influences periostin expression indirectly by modulating adipocyte differentiation and inflammatory responses, potentially affecting ECM remodeling and fibrosis. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin modulates multiple signaling pathways, including NF-κB, which can indirectly affect periostin expression by altering the inflammatory milieu and fibrotic responses. | ||||||