Periostin Activators
Common Periostin Activators include, but are not limited to Retinoic Acid, all trans CAS 302-79-4, Dexamethasone CAS 50-02-2, Thapsigargin CAS 67526-95-8, Lovastatin CAS 75330-75-5 and Roscovitine CAS 186692-46-6.
Periostin, a matricellular protein, is a component of the extracellular matrix (ECM) that plays pivotal roles in various physiological and biological processes, especially in the context of tissue development, repair, and remodeling. Functionally, periostin interacts with other ECM proteins, facilitating cellular processes like cell adhesion, migration, and signaling. It is expressed in various tissues but is particularly prominent in areas undergoing mechanical stress or injury, such as the skin, heart, and bones. Periostin has been found to be intricately involved in collagen fibrillogenesis, enhancing the structural integrity of tissues. By binding to other ECM components, periostin provides a scaffold that aids in the proper alignment of collagen fibers, ensuring tissue resilience and mechanical strength.
The chemical class of Periostin Activators represents molecules designed to augment the expression or activity of periostin. These activators can function through a plethora of mechanisms. Some might bolster the transcription of the periostin gene, while others might enhance the translation efficiency of its mRNA or stabilize the periostin protein to extend its functional lifespan within the extracellular matrix. By amplifying periostin levels or its activity, these activators aim to reinforce the tissue's structural integrity, especially in regions that undergo significant mechanical strain. In a research setting, periostin activators can be invaluable. They offer a lens through which the intricate roles of periostin in tissue biology can be explored, from its involvement in collagen fiber arrangement to its impact on cell adhesion and signaling pathways. Utilizing these activators can deepen our understanding of the multifaceted roles periostin plays in various physiological contexts, laying the groundwork for future explorations in the realm of tissue biology and mechanics.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid is involved in cell differentiation and tissue remodeling. It might upregulate periostin expression in processes where tissue remodeling and repair are paramount. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a glucocorticoid, can influence various cellular responses, including inflammation. It might elevate periostin levels as part of the tissue repair response after inflammation or injury. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin induces endoplasmic reticulum stress, which can lead to cellular responses related to tissue repair. This might stimulate periostin expression as part of the repair mechanism. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
Statins, known for lipid-lowering effects, also have pleiotropic effects on cellular processes. They might influence periostin expression in vascular tissue repair and remodeling contexts. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine affects the cell cycle. This could lead to changes in periostin expression as cells undergo repair or in tissue remodeling scenarios. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin affects cAMP levels, influencing various cellular pathways. It might modulate periostin expression in contexts related to tissue repair or stress responses. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a phytoestrogen, can modulate cell signaling pathways. It might influence periostin expression in tissue remodeling or in responses to hormonal changes. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid, an HDAC inhibitor, can modulate gene expression. It might affect periostin levels as cells undergo differentiation or tissue remodeling. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin is a chemotherapy drug. Given periostin's upregulation in certain cancers, agents like cisplatin might influence its expression as tumor cells respond to treatment. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, can affect gene expression. It might modulate periostin expression in contexts of cellular differentiation or tissue repai | ||||||