Periostin Antibody (F-10): sc-398631

Periostin Antibody (F-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects Periostin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Periostin antibody (F-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Periostin, also known as osteoblast-specific factor 2 (OSF-2), is a disulfide-linked secreted protein that plays a crucial role in cell adhesion and migration, particularly in bone and tissue remodeling. Periostin serves as a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins, facilitating osteoblast recruitment and attachment, essential for bone formation and repair. Periostin is predominantly found in the lower gastrointestinal tract, aorta, stomach, placenta, uterus, and breast tissues, with notable up-regulation in epithelial ovarian tumors and overexpression in breast cancer, highlighting potential roles in tumor progression and metastasis. Periostin expression is influenced by bone morphogenetic protein 2 (BMP2) and transforming growth factor beta 1 (TGF β 1), indicating involvement in various signaling pathways that regulate cellular processes. Structurally, Periostin features a typical signal sequence, a cysteine-rich domain, a fourfold repeated domain homologous to the insect protein fasciclin, and a C-terminal domain, which together contribute to functional properties and interactions within the extracellular matrix.

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Periostin Antibody (F-10) References:

1. Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta.  |  Horiuchi, K., et al. 1999. J Bone Miner Res. 14: 1239-49. PMID: 10404027
2. Identification and detection of the periostin gene in cardiac development.  |  Norris, RA., et al. 2004. Anat Rec A Discov Mol Cell Evol Biol. 281: 1227-33. PMID: 15532025
3. Periostin induction in tumor cell line explants and inhibition of in vitro cell growth by anti-periostin antibodies.  |  Tai, IT., et al. 2005. Carcinogenesis. 26: 908-15. PMID: 15731169
4. Immunolocalization of chick periostin protein in the developing heart.  |  Kern, CB., et al. 2005. Anat Rec A Discov Mol Cell Evol Biol. 284: 415-23. PMID: 15803479
5. Messenger RNA expression of periostin and Twist transiently decrease by occlusal hypofunction in mouse periodontal ligament.  |  Afanador, E., et al. 2005. Arch Oral Biol. 50: 1023-31. PMID: 15922993
6. Detection of betaig-H3, a TGFbeta induced gene, during cardiac development and its complementary pattern with periostin.  |  Norris, RA., et al. 2005. Anat Embryol (Berl). 210: 13-23. PMID: 16034610
7. Evidence that osteogenic progenitor cells in the human tunica albuginea may originate from stem cells: implications for peyronie disease.  |  Vernet, D., et al. 2005. Biol Reprod. 73: 1199-210. PMID: 16093362
8. Periostin in Bone Regeneration.  |  Duchamp de Lageneste, O. and Colnot, C. 2019. Adv Exp Med Biol. 1132: 49-61. PMID: 31037624
9. Periostin Promotes Cell Proliferation and Macrophage Polarization to Drive Repair after AKI.  |  Kormann, R., et al. 2020. J Am Soc Nephrol. 31: 85-100. PMID: 31690575
10. Periostin in Allergy and Inflammation.  |  Sonnenberg-Riethmacher, E., et al. 2021. Front Immunol. 12: 722170. PMID: 34512647
11. Periostin: biology and function in cancer.  |  Dorafshan, S., et al. 2022. Cancer Cell Int. 22: 315. PMID: 36224629
12. Periostin: A Novel Biomarker for Asthma.  |  Goyal, JP. and Rajvanshi, N. 2023. Indian J Pediatr. 90: 427-428. PMID: 36882661

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Periostin Antibody (F-10) has 37 citations in a variety of scientific publications.

Primary antibodies like Anti-Periostin Antibody (F-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Periostin Antibody (F-10) Specifications

Alternate Product Name: osteoblast-specific factor (OSF-2)

Product Clone Name: F-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 537-836

Epitope Target: Periostin

Epitope Species: human

Product Reactivity/Detection: Periostin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 37 citations in various scientific publications

Available Conjugates/Forms for Periostin Antibody (F-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin