PEPT2 Activators
PEPT2 Activators comprise a variety of compounds that indirectly augment the functional activity of PEPT2, a protein involved in the renal and neuronal transport of peptides. Compounds like Acivicin, Gly-Pro, and Captopril work through different mechanisms to potentially enhance PEPT2 activity. Acivicin, by inhibiting glutamine synthetase, may increase extracellular glutamine levels, indirectly upregulating PEPT2-mediated peptide transport. Gly-Pro, as a dipeptide, could directly activate PEPT2 by acting as a substrate analog, enhancing the transporter's efficiency. Captopril, an ACE inhibitor, might indirectly enhance PEPT2 activity by increasing the levels of dipeptides, which are substrates for this transporter.
Furthermore, Bestatin and Amiloride, through their roles in modulating peptidase activity and renal function, respectively, might contribute to increased substrate availability for PEPT2. Bestatin, as an aminopeptidase inhibitor, could lead to higher concentrations of oligopeptides, potentially enhancing PEPT2 transport activity. Amiloride might indirectly influence PEPT2 by altering renal tubular function. Valproic Acid and Hydrochlorothiazide, known for their effects on amino acid metabolism and diuretic properties, could also play a role in enhancing PEPT2 activity. Valproic Acid might influence the availability of peptide substrates, while Hydrochlorothiazide may affect renal function, indirectly impacting PEPT2's function. Nutrients and metabolic influencers like L-Leucine, Zinc, and D(+)Glucose, Anhydrous could enhance PEPT2 activity by modulating nutrient sensing and energy metabolism, key factors in PEPT2's role in peptide transport. (-)-Epigallocatechin Gallate and Curcumin, with their broad effects on cellular metabolism and signaling pathways, may also enhance the efficiency or expression of PEPT2. These diverse activators highlight the complex interplay of metabolic, enzymatic, and signaling pathways in regulating the activity of PEPT2, essential for peptide transport in renal and neuronal tissues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Acivicin | 42228-92-2 | sc-200498B sc-200498C sc-200498 sc-200498D | 1 mg 5 mg 10 mg 25 mg | $102.00 $408.00 $642.00 $1275.00 | 10 | |
Acivicin can enhance PEPT2 activity by inhibiting glutamine synthetase, potentially leading to an increase in extracellular glutamine levels, which may in turn upregulate PEPT2-mediated transport. | ||||||
Gly-Pro | 704-15-4 | sc-255188 | 10 g | $434.00 | ||
Gly-Pro, a dipeptide, may directly activate PEPT2 by acting as a substrate analog, potentially enhancing the transporter's affinity and efficiency in peptide transport. | ||||||
Captopril | 62571-86-2 | sc-200566 sc-200566A | 1 g 5 g | $48.00 $89.00 | 21 | |
Captopril, an ACE inhibitor, might enhance PEPT2 activity indirectly by increasing levels of dipeptides, which are substrates for PEPT2, thus potentially increasing its transport activity. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Amiloride, a diuretic, may indirectly enhance PEPT2 activity by modulating renal tubular function and electrolyte balance, potentially affecting the transporter's function in the kidney. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic Acid, an anticonvulsant, might enhance PEPT2 activity indirectly by influencing amino acid metabolism and transport, potentially increasing the availability of peptide substrates for PEPT2. | ||||||
Hydrochlorothiazide | 58-93-5 | sc-207738 sc-207738A sc-207738B sc-207738C sc-207738D | 5 g 25 g 50 g 100 g 250 g | $54.00 $235.00 $326.00 $551.00 $969.00 | ||
Hydrochlorothiazide, a thiazide diuretic, could potentially enhance PEPT2 activity by altering electrolyte balance and renal function, which may indirectly affect PEPT2's peptide transport function. | ||||||
L-Leucine | 61-90-5 | sc-364173 sc-364173A | 25 g 100 g | $21.00 $61.00 | ||
L-Leucine, an essential amino acid, might enhance PEPT2 activity by influencing amino acid sensing and signaling pathways, potentially upregulating PEPT2-mediated peptide transport. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc, an essential mineral, could enhance PEPT2 activity by modulating cellular signaling pathways involved in nutrient sensing, potentially influencing PEPT2's function in peptide transport. | ||||||
D(+)Glucose, Anhydrous | 50-99-7 | sc-211203 sc-211203B sc-211203A | 250 g 5 kg 1 kg | $37.00 $194.00 $64.00 | 5 | |
D(+)Glucose, Anhydrous might indirectly enhance PEPT2 activity by influencing cellular energy metabolism, potentially affecting the energy-dependent process of peptide transport by PEPT2. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
(-)-Epigallocatechin Gallate, a polyphenol, could potentially enhance PEPT2 activity by modulating signaling pathways involved in cellular metabolism and transport functions. | ||||||