PDPc Activators
PDPc activators can be broadly divided into two categories based on the type of signaling pathway they influence. The first category which all act to enhance the levels of intracellular cAMP. This increase in cAMP activates protein kinase A (PKA), which subsequently phosphorylates and activates PDPc. Here, the activation of PDPc is a direct consequence of an increase in cAMP levels, highlighting the central role of cAMP signaling in regulating PDPc activity.
The second category of chemical compounds act by inhibiting the activity of protein phosphatases PP1 and PP2A. Protein phosphatases are enzymes that remove phosphate groups from proteins, a process known as dephosphorylation. By inhibiting these enzymes, these compounds disrupt the dephosphorylation of PDPc, thereby maintaining it in its activated state. This mechanism of action underscores the importance of the balance between phosphorylation and dephosphorylation processes in controlling the activity of PDPc. In each case, the activation of PDPc is promoted through a fine-tuned adjustment of intracellular signaling mechanisms, demonstrating the intricate interplay between these pathways and PDPc activity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin enhances the activity of PDPc by increasing cAMP levels, which activates PKA. PKA then phosphorylates and activates PDPc, enhancing its functional activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX inhibits phosphodiesterases, leading to an increase in cAMP levels. This, in turn, activates PKA, which phosphorylates and activates PDPc. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram, a phosphodiesterase inhibitor, enhances cAMP levels, leading to the activation of PKA. Activated PKA phosphorylates and activates PDPc. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine binds to beta-adrenergic receptors, leading to an increase in intracellular cAMP levels. This activates PKA, which then phosphorylates and activates PDPc. | ||||||
Cilostamide (OPC 3689) | 68550-75-4 | sc-201180 sc-201180A | 5 mg 25 mg | $90.00 $350.00 | 16 | |
Cilostamide inhibits phosphodiesterase 3, leading to increased cAMP levels. The resulting activation of PKA phosphorylates and activates PDPc. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid inhibits protein phosphatases PP1 and PP2A, preventing dephosphorylation of PDPc, thus maintaining PDPc in its activated state. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A inhibits protein phosphatases PP1 and PP2A, preventing dephosphorylation of PDPc, thus maintaining PDPc in its activated state. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $81.00 $260.00 | 6 | |
Cantharidin inhibits protein phosphatases PP1 and PP2A, preventing dephosphorylation of PDPc, thus maintaining PDPc in its activated state. | ||||||
Endothall | 145-73-3 | sc-201325 sc-201325A | 20 mg 100 mg | $48.00 $199.00 | 1 | |
Endothall inhibits protein phosphatases PP1 and PP2A, preventing dephosphorylation of PDPc, thus maintaining PDPc in its activated state. | ||||||