PDE6G Activators

PDE6G Activators are a distinct class of chemical compounds that specifically enhance the functional activity of PDE6G, a protein involved in the hydrolysis of cyclic guanosine monophosphate (cGMP). These activators generally work by increasing the availability of cGMP, which is the direct substrate for PDE6G. Compounds like cGMP, Sodium Nitroprusside, Nitroglycerin, Isosorbide Mononitrate, Isosorbide Dinitrate, and Nitric Oxide directly increase the levels of cGMP. Nitric Oxide donors such as Sodium Nitroprusside, Nitroglycerin, Isosorbide Mononitrate, and Isosorbide Dinitrate enhance the production of cGMP by stimulating guanylate cyclase. Elevated levels of cGMP provide more substratefor PDE6G, driving its activity and thus classifying these compounds as PDE6G Activators.

In the same class of PDE6G Activators, other compounds like Theobromine, Papaverine, and Aminophylline work in a slightly different manner. They are phosphodiesterase inhibitors, but not selective towards PDE6G. Instead, they inhibit other phosphodiesterases like PDE5 and increase the available pool of cGMP for PDE6G. Theobromine, Papaverine, and Aminophylline are nonselective phosphodiesterase inhibitors that can potentially increase the availability of cGMP, leading to enhanced PDE6G activity. On the other hand, Iloprost, a prostacyclin analog, enhances PDE6G activity by increasing cAMP levels. This indirectly influences PDE6G by inhibiting PDE3, a phosphodiesterase that competes with PDE6G for cGMP, thereby boosting the availability of cGMP for PDE6G.