PDE4D Activators
PDE4D activators belong to a class of chemical compounds designed to specifically target and modulate the activity of Phosphodiesterase 4D (PDE4D), an enzyme that plays a crucial role in intracellular signaling by hydrolyzing cyclic adenosine monophosphate (cAMP). PDE4D is a member of the phosphodiesterase enzyme family, and it is predominantly found in various tissues and cell types, including the brain, immune cells, and smooth muscle. This enzyme regulates the levels of cAMP, a second messenger molecule that participates in a wide range of cellular processes, including signal transduction, gene expression, and immune response. By modulating the activity of PDE4D, these activators can influence the concentration of cAMP within cells, ultimately impacting downstream signaling events and cellular responses.
Activation of PDE4D by specific chemical compounds can have profound effects on cellular physiology, as it regulates the fine balance between cAMP production and degradation. These activators are designed to enhance the catalytic activity of PDE4D, thereby promoting the hydrolysis of cAMP to its inactive form. This modulation of cAMP levels can influence various signaling pathways and cellular functions, including neurotransmission, inflammation, and smooth muscle relaxation. Understanding the mechanisms and effects of PDE4D activators is of significant interest in molecular and cellular biology research, as it can provide insights into the intricate regulation of intracellular signaling pathways and their roles in various physiological processes. These compounds serve as valuable tools for exploring the functions of PDE4D in different cellular contexts and uncovering its contributions to normal cellular function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin may upregulate PDE4D expression by increasing intracellular cAMP levels through the activation of adenylyl cyclase, potentially leading to a compensatory increase in PDE4D to regulate cAMP. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
As a selective PDE4 inhibitor, Rolipram could indirectly induce PDE4D expression as a feedback mechanism due to elevated cAMP levels resulting from PDE4 inhibition. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $102.00 | 6 | |
Hydrocortisone might influence PDE4D expression through glucocorticoid receptor-mediated mechanisms, which are known to interact with cAMP signaling pathways. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine, a non-selective PDE inhibitor, could potentially elevate PDE4D expression as part of a cellular response to increased cAMP levels due to reduced PDE activity. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $32.00 $85.00 | 6 | |
Theophylline, another non-selective PDE inhibitor, might similarly induce PDE4D expression by increasing cAMP levels and triggering compensatory cellular responses. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 may modulate PDE4D expression through its action on G protein-coupled receptors, which can influence cAMP-mediated signaling pathways. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
(-)-Epinephrine could potentially induce PDE4D expression through β-adrenergic receptors, leading to increased cAMP levels and subsequent regulatory responses. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $326.00 $485.00 | 3 | |
L-Noradrenaline, through its action on adrenergic receptors, might influence PDE4D expression due to its role in modulating cAMP signaling pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX, a non-selective inhibitor of PDEs, may increase PDE4D expression as a part of the cellular response to elevated cAMP levels. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone might affect PDE4D expression by interacting with glucocorticoid receptors, which can have downstream effects on cAMP signaling pathways. | ||||||