PDE1B Inhibitors
PDE1B inhibitors belong to a distinctive chemical class of compounds that target the phosphodiesterase 1B enzyme, also known as PDE1B. This enzyme is a member of the phosphodiesterase superfamily and is involved in the regulation of intracellular levels of cyclic nucleotides, specifically cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). PDE1B is primarily found within various tissues and cells of the human body, where it plays a crucial role in modulating intracellular signaling pathways by hydrolyzing cAMP and cGMP.
By inhibiting PDE1B, these inhibitors interfere with its enzymatic activity, leading to elevated levels of cAMP and cGMP within cells. This modulation of cyclic nucleotide signaling can have significant effects on various cellular processes, as these molecules are involved in the regulation of diverse physiological functions. The distinct chemical structure and mechanism of action of PDE1B inhibitors make them a valuable tool for studying the intricate intracellular signaling pathways and their potential implications.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
Originally found in the periwinkle plant, vinpocetine is used as a dietary supplement and has been studied for its potential cognitive-enhancing effects. | ||||||
Enoximone | 77671-31-9 | sc-252775 sc-252775A | 10 mg 50 mg | $181.00 $728.00 | 1 | |
This compound is used as a positive inotropic agent and vasodilator in congestive heart failure and other cardiovascular conditions. | ||||||
Ketanserin tartrate | 83846-83-7 | sc-201131 sc-201131A | 50 mg 250 mg | $223.00 $791.00 | ||
While primarily known as a serotonin receptor antagonist, ketanserin also displays PDE1B inhibitory activity. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $109.00 $322.00 | 3 | |
Cilostazol is a vasodilator and antiplatelet agent that inhibits PDE1B. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
While primarily known as a PDE4 inhibitor, rolipram also exhibits some degree of selectivity towards PDE1B. It has been studied for its potential in affecting depression and other neurological disorders. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $165.00 $697.00 | 7 | |
Milrinone is a phosphodiesterase inhibitor with selectivity for PDE3 and PDE1B. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $57.00 $245.00 $831.00 $1331.00 | 4 | |
While typically known as an antibiotic, erythromycin has been found to inhibit PDE1B as well. Its role as a PDE1B inhibitor is not as well-studied as its antibiotic properties. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $105.00 $250.00 | 8 | |
Originally developed as a PDE5 inhibitor, zaprinast also has moderate PDE1B inhibitory activity. It has been investigated for its potential vasodilatory effects. | ||||||