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Ketanserin tartrate (CAS 83846-83-7)

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Application:
Ketanserin tartrate is a selective serotonin agonist
CAS Number:
83846-83-7
Purity:
≥99%
Molecular Weight:
545.5
Molecular Formula:
C22H22FN3O3•C4H6O6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ketanserin tartrate is a salt of Ketanserin. Ketanserin is reported to have a high affinity for multiple G protein-coupled receptors, such as serotonin receptors. Ketanserin is a selective SR-2/SR-1C antagonist. It has been used to distinguish between SR-1D and SR-1B subtypes. Additional studies have noted that Ketanserin is able to differentiate between recombinant human forms of these receptors with a higher affinity for SR-1Dα receptors compared to SR-1Dβ receptors. Ketanserin tartrate is an inhibitor of SR-2A and SR-2C.


Ketanserin tartrate (CAS 83846-83-7) References

  1. Activation of spinal serotonin(2A/2C) receptors augments nociceptive responses in the rat.  |  Kjørsvik, A., et al. 2001. Brain Res. 910: 179-81. PMID: 11489268
  2. The antiallodynic effect of Neurotropin is mediated via activation of descending pain inhibitory systems in rats with spinal nerve ligation.  |  Okazaki, R., et al. 2008. Anesth Analg. 107: 1064-9. PMID: 18713930
  3. Effects of ketanserin tartrate on 3-hydroxy, 3-methylglutaryl coenzyme A reductase activity in cultured human skin fibroblasts.  |  Suzukawa, M. and Nakamura, H. 1990. Cardiovasc Drugs Ther. 4 Suppl 1: 69-72. PMID: 1981023
  4. Spinal 5-HT receptors that contribute to the pain-relieving effects of spinal cord stimulation in a rat model of neuropathy.  |  Song, Z., et al. 2011. Pain. 152: 1666-1673. PMID: 21514998
  5. Effect of ketanserin tartrate on HMG CoA reductase and LDL receptor activity in cultured human skin fibroblasts.  |  Suzukawa, M. and Nakamura, H. 1990. Eur J Clin Pharmacol. 39: 217-20. PMID: 2257855
  6. Effect of Systemic Application of 5-Hydroxytryptamine on Hypoglossal Nerve Discharge in Anesthetized Rats.  |  Tu, X., et al. 2015. J Mol Neurosci. 57: 435-45. PMID: 26076739
  7. Discovery and Structure-Based Optimization of 6-Bromotryptamine Derivatives as Potential 5-HT2A Receptor Antagonists.  |  Ding, L., et al. 2015. Molecules. 20: 17675-83. PMID: 26404234
  8. Involvement of 5-HT2A, 5-HT2B and 5-HT2C receptors in mediating the ventrolateral orbital cortex-induced antiallodynia in a rat model of neuropathic pain.  |  Xu, WJ., et al. 2020. Neuroreport. 31: 167-173. PMID: 31789691
  9. Vascular effects of ketanserin (R 41 468), a novel antagonist of 5-HT2 serotonergic receptors.  |  Van Nueten, JM., et al. 1981. J Pharmacol Exp Ther. 218: 217-30. PMID: 6113280
  10. [3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites. Binding properties, brain distribution, and functional role.  |  Leysen, JE., et al. 1982. Mol Pharmacol. 21: 301-14. PMID: 7099138
  11. Differences in the effects of ketanserin and GR127935 on 5-HT-receptor mediated responses in rabbit saphenous vein and guinea-pig jugular vein.  |  Razzaque, Z., et al. 1995. Eur J Pharmacol. 283: 199-206. PMID: 7498311
  12. Ketanserin and ritanserin discriminate between recombinant human 5-HT1D alpha and 5-HT1D beta receptor subtypes.  |  Zgombick, JM., et al. 1995. Eur J Pharmacol. 291: 9-15. PMID: 8549648
  13. Ketanserin in the treatment of protamine-induced pulmonary hypertension.  |  van der Starre, PJ. and Solinas, C. 1996. Tex Heart Inst J. 23: 301-4. PMID: 8969033

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ketanserin tartrate, 50 mg

sc-201131
50 mg
$219.00

Ketanserin tartrate, 250 mg

sc-201131A
250 mg
$775.00