PCIF1 Inhibitors
Chemical inhibitors of PCIF1 include a range of compounds that target various signaling pathways and kinases which are crucial for the functional regulation of the protein. Staurosporine, a broad-spectrum protein kinase inhibitor, can inhibit PCIF1 by interfering with the phosphorylation process that is essential for the protein's function. Similarly, Bisindolylmaleimide I, by specifically inhibiting protein kinase C (PKC), can prevent the PKC-dependent phosphorylation that PCIF1 may require for its activity. The chemical H-89 targets protein kinase A (PKA) and can inhibit PCIF1 by blocking the PKA-dependent phosphorylation that may be essential for the protein's activity. LY294002 and Wortmannin are both phosphoinositide 3-kinases (PI3K) inhibitors that can inhibit PCIF1 by interfering with PI3K signaling, which may be a pathway that PCIF1 relies on for its function.
Furthermore, U0126 and PD98059, which are inhibitors of MEK, part of the MAPK/ERK pathway, can lead to the functional inhibition of PCIF1 by preventing its regulation through this pathway. SB203580 and SP600125, inhibitors of p38 MAP kinase and c-Jun N-terminal kinase (JNK) respectively, can inhibit PCIF1 by disrupting signaling pathways that may control the stability and function of the protein. Rapamycin, as an mTOR inhibitor, can inhibit PCIF1 by blocking mTOR signaling, which could be crucial for PCIF1's activity. GF109203X, another PKC inhibitor, can inhibit PCIF1 by preventing the phosphorylation that is possibly essential for PCIF1's regulation. Lastly, Triciribine, by inhibiting the Akt pathway, can inhibit PCIF1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. PCIF1 is known to be phosphorylated which can be essential for its function. Inhibition of the kinases responsible for this phosphorylation by Staurosporine could lead to functional inhibition of PCIF1. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
This chemical is a specific inhibitor of protein kinase C (PKC). Since PKC-mediated signaling could be necessary for PCIF1 activation or stabilization, Bisindolylmaleimide I could inhibit PCIF1 activity by preventing its PKC-dependent phosphorylation. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
H-89 is a protein kinase A (PKA) inhibitor. If PKA phosphorylation is required for PCIF1 activity, then H-89 could inhibit PCIF1 by blocking its PKA-dependent phosphorylation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a phosphoinositide 3-kinases (PI3K) inhibitor. PI3K pathway is implicated in a multitude of cellular functions, and if PCIF1 function is PI3K-dependent, LY294002 could inhibit PCIF1 by blocking this pathway. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of mitogen-activated protein kinase (MEK), which is upstream of extracellular signal-related kinases (ERKs). As ERKs can regulate protein function, U0126 could inhibit PCIF1 by preventing its ERK-dependent regulation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAP kinase. If the p38 MAPK pathway is involved in regulating PCIF1, then SB203580 could inhibit PCIF1 by blocking this signaling pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). The JNK pathway can regulate protein stability and function, so inhibition by SP600125 could lead to a functional inhibition of PCIF1. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K. If PCIF1 relies on PI3K signaling for its function, inhibition by Wortmannin could result in its functional inhibition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor, and since mTOR signaling is crucial for many cellular processes, if PCIF1 function is mTOR-dependent, Rapamycin could inhibit PCIF1 activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which is part of the MAPK/ERK pathway. As this pathway can control various protein functions, inhibition by PD98059 could lead to functional inhibition of PCIF1. | ||||||