PCIA1 Activators
PCIA1 Activators encompass a diverse array of chemical compounds that indirectly facilitate the functional enhancement of PCIA1 through a variety of signaling pathways. Forskolin and Ionomycin, by increasing intracellular cAMP and calcium levels respectively, initiate a cascade of phosphorylation events through activated PKA and calcium-dependent kinases which are poised to enhance PCIA1 activity if it is influenced by these kinases.
Similarly, the application of PMA, which stimulates PKC, could lead to the activation of PCIA1 if it is situated within a PKC-regulated pathway or is a substrate thereof. In parallel, compounds such as EGCG and Genistein, which inhibit specific protein kinases, and LY294002, a PI3K inhibitor, may relieve PCIA1 from negative regulation exerted by these kinases or the PI3K/AKT pathway, thus promoting its activity. These compounds, through their targeted actions, serve to tip the balance of cellular signaling in favor of PCIA1 activation without directly affecting its expression levels.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can then phosphorylate and enhance the activity of PCIA1 if PCIA1 is a substrate for PKA or part of a PKA-regulated pathway. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate substrates including PCIA1 if it is part of a PKC-regulated signaling cascade, thereby enhancing its activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin increases intracellular calcium levels, which can activate calcium-dependent proteins and pathways potentially leading to the activation of PCIA1 if it is calcium-sensitive. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P engages with G-protein-coupled receptors (GPCRs) to activate downstream kinase signaling pathways which could enhance PCIA1 activity if it is involved in such pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG inhibits certain kinases and could result in the enhancement of PCIA1 activity by reducing competitive signaling or through pathway crosstalk if PCIA1 is regulated by these kinases. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that can modulate downstream AKT signaling, potentially enhancing the activity of PCIA1 if it is negatively regulated by PI3K/AKT pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that could enhance the activity of PCIA1 by inhibiting p38 MAPK, assuming PCIA1 is part of a signaling process that is negatively regulated by p38 MAPK. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin elevates intracellular calcium levels by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA), which may activate PCIA1 if it is influenced by calcium signaling. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
db-cAMP is a cAMP analog that activates cAMP-dependent pathways, potentially enhancing PCIA1 activity if it is part of or regulated by such pathways. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can activate stress-activated protein kinases (SAPKs), potentially enhancing PCIA1 if it is activated as part of a stress response or by SAPK signaling. | ||||||