PCDHGC Activators

PCDHGC, or Protocadherin Gamma Cluster, represents a group of genes within the larger family of protocadherins, which are part of the cadherin superfamily of cell adhesion molecules. Protocadherins are critical in the nervous system, playing a significant role in establishing and maintaining specific neuronal connections. The Gamma Cluster of protocadherins consists of numerous closely related genes (like PCDHGA and PCDHGB series) and is notable for its diversity and complexity.

The expression of PCDHGC genes is predominantly observed in the brain, where they contribute to the development and functioning of the nervous system. These molecules are essential for neural circuit formation, neuronal differentiation, and synaptic specificity. By mediating cell-cell interactions in the developing nervous system, PCDHGC genes ensure that neurons form the correct connections, which is crucial for proper brain function and the establishment of complex neural networks.Variations in the PCDHGC genes can result in a diverse array of cell adhesion molecules, providing a molecular basis for the specificity of neuronal connections. This diversity is achieved through alternative splicing and other genetic mechanisms, allowing a large number of different protocadherin proteins to be produced from a relatively small number of genes.