PCDHGC Antibody (5A2): sc-130556

PCDHGC Antibody (5A2) is a mouse monoclonal IgA kappa light chain antibody that detects PCDHGC protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PCDHGC antibody (5A2) is available as the non-conjugated format. Protocadherins, including PCDHGC, play a crucial role in establishing and maintaining neuronal connections, vital for proper brain function and communication between neurons. PCDHGC protein is primarily located in synaptic regions of neurons, where PCDHGC contributes to synaptic specificity and stability. Such localization enables PCDHGC to interact with other synaptic proteins, facilitating synapse formation and ensuring effective neurotransmission. PCDHGC family consists of 22 isoforms sharing a common C-terminal cytoplasmic domain, with each isoform differing in extracellular and transmembrane regions, potentially influencing interactions with other proteins and functional roles in synaptic physiology. Understanding PCDHGC dynamics and interactions remains critical for elucidating mechanisms underlying synaptic plasticity and overall functioning of neural circuits.

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PCDHGC Antibody (5A2) References:

1. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.  |  Wu, Q., et al. 2001. Genome Res. 11: 389-404. PMID: 11230163
2. Gamma-protocadherins are targeted to subsets of synapses and intracellular organelles in neurons.  |  Phillips, GR., et al. 2003. J Neurosci. 23: 5096-104. PMID: 12832533
3. Variation in the protocadherin gamma A gene cluster.  |  Kirov, G., et al. 2003. Genomics. 82: 433-40. PMID: 13679023
4. The b1 isoform of protocadherin-gamma (Pcdhgamma) interacts with the microtubule-destabilizing protein SCG10.  |  Gayet, O., et al. 2004. FEBS Lett. 578: 175-9. PMID: 15581637
5. Identification and characterization of coding single-nucleotide polymorphisms within human protocadherin-alpha and -beta gene clusters.  |  Miki, R., et al. 2005. Gene. 349: 1-14. PMID: 15777644
6. delta-Protocadherins: a gene family expressed differentially in the mouse brain.  |  Vanhalst, K., et al. 2005. Cell Mol Life Sci. 62: 1247-59. PMID: 15905963
7. Protocadherin family: diversity, structure, and function.  |  Morishita, H. and Yagi, T. 2007. Curr Opin Cell Biol. 19: 584-92. PMID: 17936607
8. Clustered protocadherin family.  |  Yagi, T. 2008. Dev Growth Differ. 50 Suppl 1: S131-40. PMID: 18430161
9. gamma-Protocadherins regulate neuronal survival but are dispensable for circuit formation in retina.  |  Lefebvre, JL., et al. 2008. Development. 135: 4141-51. PMID: 19029044
10. CRISPR/Cas9 interrogation of the mouse Pcdhg gene cluster reveals a crucial isoform-specific role for Pcdhgc4.  |  Garrett, AM., et al. 2019. PLoS Genet. 15: e1008554. PMID: 31877124
11. Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.  |  Mancia Leon, WR., et al. 2020. Elife. 9: PMID: 32633719
12. γ-Protocadherins control synapse formation and peripheral branching of touch sensory neurons.  |  Meltzer, S., et al. 2023. Neuron. 111: 1776-1794.e10. PMID: 37028432

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PCDHGC Antibody (5A2) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-PCDHGC Antibody (5A2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PCDHGC Antibody (5A2) Specifications

Alternate Product Name: PCDHGC

Product Clone Name: 5A2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgA kappa light chain

Amino Acids:

Epitope Target: PCDHGC

Epitope Species: mouse

Product Reactivity/Detection: proteins containing the conserved C-terminal region of PCDHGC

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgA kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for PCDHGC Antibody (5A2): N/A