Pcdhgb4 Inhibitors
Chemical inhibitors of Pcdhgb4 can affect the protein's activity and functioning in various ways, depending on the mechanism of the inhibitor in question. Tetrodotoxin, for instance, inhibits voltage-gated sodium channels, which are crucial for the initiation and propagation of action potentials within neurons. This inhibition can disrupt neural activity, potentially reducing the functional expression of Pcdhgb4, which is known to play a role in neural network formation and maintenance. Similarly, conotoxin targets voltage-gated calcium channels on presynaptic terminals, essential for neurotransmitter release. As Pcdhgb4 is involved in synaptic interactions and neural circuitry, conotoxin's inhibition of these channels can impair synaptic transmission and, thereby, Pcdhgb4's activity related to these processes.
Furthermore, chemicals like Bafilomycin A1 and Latrunculin A disrupt intracellular processes and cytoskeletal dynamics that are fundamental for Pcdhgb4's role in the neuron. Bafilomycin A1 specifically inhibits the vacuolar-type H+-ATPase, disrupting endosomal acidification and trafficking necessary for membrane protein recycling, which includes Pcdhgb4. Latrunculin A, on the other hand, binds to actin monomers and prevents their polymerization, thereby disrupting the actin cytoskeleton, which is essential for Pcdhgb4-mediated cell adhesion and signaling. Other chemical inhibitors like W-7 Hydrochloride and KN-93 affect calcium signaling pathways. W-7 Hydrochloride is a calmodulin antagonist that inhibits calcium-calmodulin-dependent protein kinases, while KN-93 is a selective inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII). Both of these pathways are important for Pcdhgb4's role in neuronal function and plasticity, and their inhibition can impair synaptic function and stability. Similarly, Go 6983, ML-7, Y-27632, PD 98059, and LY294002 each target different kinases or signaling molecules-such as protein kinase C, myosin light chain kinase, Rho-associated protein kinase, mitogen-activated protein kinase kinase, and phosphatidylinositol 3-kinase, respectively-that are involved in processes critical for Pcdhgb4's function in cell adhesion, signaling, and maintaining synaptic integrity. By inhibiting these molecules, the chemicals can alter cellular dynamics and signaling pathways, which are integral for the role of Pcdhgb4 in neurons.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 is a specific inhibitor of the vacuolar-type H+-ATPase (V-ATPase). By inhibiting V-ATPase, it disrupts endosomal acidification and trafficking, which are crucial for membrane protein recycling, including proteins like Pcdhgb4 that are involved in cell adhesion and signaling in neurons. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A binds to actin monomers and prevents their polymerization, disrupting actin cytoskeleton dynamics. As Pcdhgb4 is involved in cell-cell adhesion and signaling, the integrity of the cytoskeleton is essential for its function. Disruption of the actin cytoskeleton, therefore, can inhibit Pcdhgb4-mediated cell adhesion. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
W-7 Hydrochloride is a calmodulin antagonist that inhibits calcium-calmodulin-dependent protein kinases. Since Pcdhgb4 is part of neural processes, the inhibition of calcium-calmodulin-dependent signaling can disrupt downstream signaling pathways necessary for Pcdhgb4's role in neuronal function and plasticity. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
KN-93 is a selective inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII). Pcdhgb4 is implicated in neural functions, and CaMKII plays a critical role in synaptic plasticity. Inhibition of CaMKII can impair synaptic function and plasticity, thereby indirectly inhibiting Pcdhgb4-related activities in neurons. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Go 6983 is a potent protein kinase C (PKC) inhibitor. PKC is involved in many signaling pathways, including those that regulate cytoskeletal organization and cell adhesion. By inhibiting PKC, Go 6983 can impair cellular processes in which Pcdhgb4 is implicated, particularly in neural cells where PKC signaling affects synaptic stability and plasticity. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 is an inhibitor of myosin light chain kinase (MLCK), which is involved in the regulation of actin-myosin contraction in cells. Pcdhgb4's function in cell adhesion and signaling would be affected by changes in actin-myosin dynamics, and ML-7-mediated inhibition of MLCK can result in altered cellular mechanics that indirectly inhibit Pcdhgb4 function. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of the Rho-associated protein kinase (ROCK). ROCK is involved in regulating cytoskeletal dynamics and cell adhesion. Inhibition of ROCK can lead to reduced cell tension and altered adhesion, which can indirectly inhibit the function of Pcdhgb4 in cell-cell interactions and signaling pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), which is upstream of extracellular signal-regulated kinase (ERK). Pcdhgb4 is involved in signaling pathways in the central nervous system, and inhibition of MEK/ERK signaling can disrupt these pathways, thereby indirectly inhibiting Pcdhgb4's role in these processes. | ||||||