PCDHB11 Inhibitors
The class of chemicals known as PCDHB11 inhibitors encompasses compounds that indirectly modulate the activity or function of the PCDHB11 protein, primarily by influencing related cellular signaling and adhesion processes. Considering that PCDHB11 is a member of the protocadherin family, compounds like Blebbistatin and Y-27632, which influence cell adhesion and cytoskeleton dynamics, serve as apt representatives. These inhibitors target non-muscle myosin II and Rho-associated protein kinase (ROCK), respectively, to exert effects on cellular structures and signaling related to protocadherins.
Furthermore, signaling modulators like NSC 23766, LY294002, and U0126 can impact Rac1, PI3K, and MEK1/2 pathways, respectively. These pathways are intrinsic to cellular communication and can indirectly affect protocadherin-mediated functions. Similarly, Wiskostatin, which influences the N-WASP-Arp2/3 pathway, and Latrunculin A, which disrupts actin polymerization, introduce changes to the cellular environment that can indirectly modulate protocadherin activity. Other kinase inhibitors in this category, such as PD98059, SP600125, and Staurosporine, further solidify the intricate relationship between cellular signaling, adhesion, and protocadherin function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Inhibitor of non-muscle myosin II, which can influence cell adhesion and cytoskeleton dynamics. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Rho-associated protein kinase (ROCK) inhibitor that can modulate cell adhesion processes. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
Inhibits the N-WASP-Arp2/3 pathway, potentially affecting cellular processes associated with protocadherins. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Disrupts actin polymerization, affecting cell morphology and potentially protocadherin-mediated cell adhesion. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor that affects downstream signaling pathways, potentially influencing protocadherin activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
Another MEK inhibitor, influencing ERK signaling cascades that can relate to protocadherin activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor that modulates downstream cell signaling, potentially affecting protocadherin functions. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
General kinase inhibitor that can broadly affect cellular signaling, potentially impacting protocadherin activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
P38 MAPK inhibitor that can modulate cellular signaling, potentially relating to protocadherin functions. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
Src family kinase inhibitor that can modulate signaling pathways, potentially influencing protocadherin activity. | ||||||