PC-1 Activators
PC-1 Activators refers to chemicals that can activate polycystin-1 (PC-1), a protein involved in various cellular processes including cell adhesion, cell-cell/matrix interactions, and mechanosensation. The activation of PC-1 is largely regulated by phosphorylation and dephosphorylation events, which can be influenced by various cellular signaling pathways. Forskolin, IBMX, Rolipram, Epinephrine, and Isoproterenol are compounds that can activate PC-1 by increasing intracellular cAMP levels, which leads to the activation of PKA. PKA is a kinase that can phosphorylate and activate PC-1, thereby regulating its function. Sildenafil operates in a similar manner,but it increases intracellular cGMP levels that can activate PKG, another kinase that phosphorylates and activates PC-1. Valsartan and Verapamil can activate PC-1 by decreasing intracellular calcium levels. Low calcium levels decrease the activity of calcineurin, a phosphatase that dephosphorylates and inactivates PC-1. Thus, by reducing calcineurin activity, these compounds lead to decreased dephosphorylation and increased activation of PC-1.
Rapamycin and Metformin can activate PC-1 by modulating the mTOR pathway. Rapamycin, an mTOR inhibitor, decreases the phosphorylation of S6K1, leading to increased IRS1 activity. This results in increased PI3K activity and PIP3 levels, activating Akt, which phosphorylates and activates PC-1. Metformin operates similarly, but it increases AMPK activity, leading to the phosphorylation and activation of TSC2 and subsequent downregulation of mTOR activity. Finally, LY294002 and Pioglitazone can activate PC-1 by modulating PIP3 levels. LY294002, a PI3K inhibitor, decreases PIP3 levels and increases PTEN activity, leading to decreased Akt activity and subsequent dephosphorylation and activation of PC-1. Pioglitazone, by activating PPARγ, increases the expression of PTEN, leading to similar effects. This group of chemicals known as PC-1 Activators comprises a diverse array of compounds that modulate different cellular pathways to influence the phosphorylation state and, consequently, the activation of PC-1.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an adenylate cyclase activator. It increases the production of cyclic AMP (cAMP), which can induce the activation of PKA (protein kinase A). PKA phosphorylates and activates PC-1. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective phosphodiesterase inhibitor. By inhibiting phosphodiesterases, IBMX increases the intracellular concentration of cAMP, which can lead to the activation of PKA and subsequent phosphorylation and activation of PC-1. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective phosphodiesterase-4 inhibitor. It can increase the intracellular concentration of cAMP, leading to the activation of PKA and subsequent phosphorylation and activation of PC-1. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine is an adrenergic receptor agonist. By activating adrenergic receptors, Epinephrine can increase intracellular cAMP levels, leading to the activation of PKA and subsequent phosphorylation and activation of PC-1. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic agonist. It can increase intracellular cAMP levels, leading to the activation of PKA and subsequent phosphorylation and activation of PC-1. | ||||||
Valsartan | 137862-53-4 | sc-220362 sc-220362A sc-220362B | 10 mg 100 mg 1 g | $40.00 $92.00 $122.00 | 4 | |
Valsartan is an angiotensin II receptor antagonist. By blocking angiotensin II receptors, Valsartan can decrease intracellular calcium levels, which can decrease the activity of calcineurin. Decreased calcineurin activity can lead to decreased dephosphorylation and increased activation of PC-1. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is a calcium channel blocker. By blocking calcium channels, Verapamil can decrease intracellular calcium levels, which can decrease the activity of calcineurin and lead to decreased dephosphorylation and increased activation of PC-1. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor. By inhibiting mTOR, Rapamycin can decrease the phosphorylation of S6K1, leading to decreased inhibition of the insulin receptor substrate 1 (IRS1). Increased IRS1 activity can lead to increased PI3K activity, leading to increased PIP3 levels and subsequent activation of Akt. Akt can phosphorylate and activate PC-1. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin can increase AMPK activity. AMPK can phosphorylate and activate TSC2, leading to decreased mTOR activity. Reduced mTOR activity can lead to decreased phosphorylation of S6K1 and increased IRS1 activity, leading to increased PI3K activity, increased PIP3 levels, and subsequent activation of Akt. Akt can phosphorylate and activate PC-1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. By inhibiting PI3K, LY294002 can decrease PIP3 levels and increase PTEN activity. Increased PTEN activity can further decrease PIP3 levels, leading to decreased Akt activity and subsequent dephosphorylation and activation of PC-1. | ||||||