PC-1 Antibody (H-7): sc-393419
- PC-1 Antibody (H-7) is a mouse monoclonal IgG2b κ PC-1 antibody, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 9-36 at the N-terminus of PC-1 of human origin
- PC-1 Antibody (H-7) is recommended for detection of PC-1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-PC-1 Antibody (H-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PC-1 Antibody (H-7) for WB and IHC(P) applications. These reagents are now offered in bundles with PC-1 Antibody (H-7) (see ordering information below).
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PC-1 Antibody (H-7) is a mouse monoclonal IgG2b kappa light chain antibody that detects PC-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PC-1 (H-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PC-1 protein, also known as ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) or membrane component, chromosome 6, surface marker-1 (M6S1), plays a crucial role in regulating nucleotide metabolism and is involved in the hydrolysis of extracellular nucleotides, which is essential for maintaining cellular homeostasis and signaling. PC-1 expression is notably restricted to specific tissues, including plasma cells, hepatocytes, renal tubules, salivary duct epithelium, epididymis, capillary endothelium in the brain, and chondrocytes. PC-1′s function is particularly significant due to potential involvement in insulin resistance associated with non-insulin-dependent diabetes mellitus (NIDDM), where PC-1 may interact directly with the insulin receptor, contributing to the pathophysiology of the disease. PC-1 gene is located on human chromosome 6q22-q23, a region frequently implicated in deletions related to human lymphoid neoplasia, highlighting PC-1′s importance in both metabolic and oncological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PC-1 Antibody (H-7) References:
- Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit. | Maddux, BA. and Goldfine, ID. 2000. Diabetes. 49: 13-9. PMID: 10615944
- Plasma cell membrane glycoprotein gene Pca-1 (alkaline phosphodiesterase I) is linked to the proto-oncogene Myb on mouse chromosome 10. | Buckley, MF. and Goding, JW. 1992. Immunogenetics. 36: 199-201. PMID: 1351877
- Plasma cell membrane glycoprotein PC-1. cDNA cloning of the human molecule, amino acid sequence, and chromosomal location. | Buckley, MF., et al. 1990. J Biol Chem. 265: 17506-11. PMID: 2211644
- Distribution of the murine plasma cell antigen PC-1 in non-lymphoid tissues. | Harahap, AR. and Goding, JW. 1988. J Immunol. 141: 2317-20. PMID: 3262656
- Surface alloantigens of plasma cells. | Takahashi, T., et al. 1970. J Exp Med. 131: 1325-41. PMID: 5419273
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PC-1 Antibody (H-7) | sc-393419 | 200 µg/ml | $316.00 | |||
PC-1 Antibody (H-7): m-IgG Fc BP-HRP Bundle | sc-530450 | 200 µg Ab; 10 µg BP | $354.00 | |||
PC-1 Antibody (H-7): m-IgGκ BP-HRP Bundle | sc-523938 | 200 µg Ab, 40 µg BP | $354.00 | |||
PC-1 Antibody (H-7): m-IgG2b BP-HRP Bundle | sc-550189 | 200 µg Ab; 10 µg BP | $354.00 | |||
PC-1 Antibody (H-7) AC | sc-393419 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PC-1 Antibody (H-7) HRP | sc-393419 HRP | 200 µg/ml | $316.00 | |||
PC-1 Antibody (H-7) FITC | sc-393419 FITC | 200 µg/ml | $330.00 | |||
PC-1 Antibody (H-7) PE | sc-393419 PE | 200 µg/ml | $343.00 | |||
PC-1 Antibody (H-7) Alexa Fluor® 488 | sc-393419 AF488 | 200 µg/ml | $357.00 | |||
PC-1 Antibody (H-7) Alexa Fluor® 546 | sc-393419 AF546 | 200 µg/ml | $357.00 | |||
PC-1 Antibody (H-7) Alexa Fluor® 594 | sc-393419 AF594 | 200 µg/ml | $357.00 | |||
PC-1 Antibody (H-7) Alexa Fluor® 647 | sc-393419 AF647 | 200 µg/ml | $357.00 | |||
PC-1 Antibody (H-7) Alexa Fluor® 680 | sc-393419 AF680 | 200 µg/ml | $357.00 | |||
PC-1 Antibody (H-7) Alexa Fluor® 790 | sc-393419 AF790 | 200 µg/ml | $357.00 | |||
PC-1 (H-7) Neutralizing Peptide | sc-393419 P | 100 µg/0.5 ml | $68.00 |