Pax-8 Activators
The class of chemicals known as Pax-8 activators encompasses a range of compounds that influence the activity of the Pax-8 protein indirectly. These compounds primarily function by modulating endocrine pathways, cellular signaling mechanisms, or nutrient availability, which are critical for thyroid cell development and function. Pax-8, being a key transcription factor in these processes, can be affected by changes in these pathways. Compounds such as Retinoic Acid, Lithium, Levothyroxine, Methimazole, and Propylthiouracil interact with or influence the thyroid hormone pathway. Thyroid hormones are crucial regulators of gene expression in thyroid cells, and their levels and activity can directly or indirectly impact the expression of Pax-8. For instance, alterations in thyroid hormone synthesis or signaling, as caused by Methimazole or Levothyroxine, could lead to compensatory changes in the expression of thyroid-specific genes, including Pax-8. Similarly, Lithium, known to affect thyroid function, may also influence Pax-8 expression as part of its broader effects on thyroid cell biology.
Nutrients like Iodide and Selenium are essential for thyroid hormone metabolism. Variations in the levels of these nutrients can affect thyroid function and consequently influence the expression of genes like Pax-8, which play a critical role in thyroid cell development and function. Iodide, being a key component of thyroid hormones, and Selenium, a crucial element in the metabolism of these hormones, can indirectly modulate Pax-8 activity through their effects on thyroid hormone synthesis and function. In addition to these, compounds that affect intracellular signaling mechanisms, such as cAMP, VEGFR inhibitors, MEK inhibitors, and γ-secretase inhibitors, also activate Pax-8 activity. These compounds act on various signaling pathways that are not exclusively thyroid-specific but can have cascading effects on cellular processes, including those in thyroid cells. Changes in these signaling pathways might indirectly affect the expression of Pax-8 by altering the cellular context in which Pax-8 functions.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a metabolite of Vitamin A, influences gene expression through its receptors. It can modulate signaling pathways that impact thyroid development and function, potentially affecting Pax-8 expression or activity in thyroid cells. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium is known to affect thyroid function, potentially by influencing signaling pathways within thyroid cells. These effects could lead to changes in the expression of genes involved in thyroid development, including Pax-8. | ||||||
Methimazole | 60-56-0 | sc-205747 sc-205747A | 10 g 25 g | $69.00 $110.00 | 4 | |
Methimazole, used in the management of hyperthyroidism, affects thyroid hormone synthesis. Alterations in thyroid hormone levels can influence the expression of thyroid-specific genes, potentially including Pax-8. | ||||||
6-Propyl-2-thiouracil | 51-52-5 | sc-214383 sc-214383A sc-214383B sc-214383C | 10 g 25 g 100 g 1 kg | $36.00 $55.00 $220.00 $1958.00 | ||
6-Propyl-2-thiouracil, another agent used in hyperthyroidism, works similarly to Methimazole. It can indirectly affect the expression of genes involved in thyroid development and function, potentially impacting Pax-8 activity. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $61.00 | 1 | |
Selenium is crucial for thyroid hormone metabolism. Its presence or deficiency can influence thyroid function, potentially affecting the expression of thyroid-specific genes, including Pax-8. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
This compound can influence numerous signaling pathways in cells. In thyroid cells, changes in cAMP levels can impact gene expression, potentially affecting Pax-8. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases intracellular cAMP levels. In thyroid cells, elevated cAMP can influence the expression of thyroid-specific genes, potentially including Pax-8. | ||||||
KI 8751 | 228559-41-9 | sc-203090 | 5 mg | $139.00 | 2 | |
KI-8751 is a VEGFR inhibitor. Although primarily focused on angiogenesis, its influence on cellular signaling might indirectly affect gene expression patterns in thyroid cells, potentially impacting Pax-8. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
DAPT is a γ-secretase inhibitor and can influence Notch signaling. Changes in Notch signaling might indirectly affect the expression of genes involved in thyroid development and function, including Pax-8. | ||||||