Molecular structure of KI 8751, CAS Number: 228559-41-9
KI 8751 (CAS 228559-41-9)
See product citations (2)
Application:
KI 8751 is a cell-permeable Flk-1 (VEGFR-2) and c-Kit inhibitor
CAS Number:
228559-41-9
Molecular Weight:
469.4
Molecular Formula:
C24H18F3N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A cell-permeable quinolyloxyphenyl-urea compound that acts as a VEGFR-2-selective inhibitior in both cell-based (IC50 = 0.9 nM in VEGF-induced receptor phosphorylation) and cell-free (IC50 = 4.0 nM in kinase reactions) assays. It inhibits c-Kit, PDGFRa, and FGFR-2 only at much higher concentrations (IC50 = 40, 67, and 170 µM, respectively, in cell-based assays), while exhibiting no effect against eight other commonly studied receptor and non-receptor kinases even at concentrations as high as 10 µM. Effectively blocks VEGF-dependent, but not VEGF-independent, cell proliferationin vitro.
KI 8751 (CAS 228559-41-9) References
Kubo, K., et al. 2005. J. Med. Chem. 48, 1359. S: 22-24/25-36/37/39Inhibitor of:
Angiogenesis, E130203B14Rik, Flk-1, MOB3A, T2R04, and T2R21.Activator of:
Pax-8, SERHL, V1RG1, and V1RG11.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KI 8751, 5 mg | sc-203090 | 5 mg | $142.00 |