Pax-2 Activators
Pax-2, a member of the paired box (Pax) family of transcription factors, plays a pivotal role in embryonic development, particularly in the formation of the kidney and the central nervous system. Activating Pax-2 can have important implications in promoting tissue development and regeneration. Several chemical activators have been identified to modulate Pax-2 expression and activity. One class of Pax-2 activators includes compounds that target specific receptors or nuclear receptors, such as Retinoic Acid and 1,25-Dihydroxyvitamin D3 (Calcitriol). These compounds can activate retinoic acid receptors (RARs) and vitamin D receptors (VDRs), respectively, which directly bind to regulatory regions of the Pax-2 gene and promote its transcription. Activation of these receptors can enhance Pax-2 expression, especially in cells where Pax-2 plays a critical role, such as renal cells. Forskolin and Ginkgolide B are activators that influence Pax-2 through the cyclic AMP (cAMP) pathway. Forskolin activates adenylate cyclase, leading to increased cAMP levels and subsequent activation of protein kinase A (PKA). PKA activation can influence Pax-2 expression through PKA-mediated signaling pathways and transcriptional regulation. Similarly, Ginkgolide B inhibits cAMP phosphodiesterase, leading to increased cAMP levels and PKA activation, indirectly modulating Pax-2 expression.
Bromodomain inhibitors like I-BET151 and JQ1 target proteins like BRD4, which are involved in transcriptional regulation. Inhibition of BRD4 can indirectly impact Pax-2 by affecting chromatin accessibility and transcriptional regulation at the Pax-2 gene locus, leading to increased Pax-2 expression. Additionally, natural products like Nicotinamide and Chrysin can influence Pax-2 through PKA activation. Nicotinamide activates the SIRT1 enzyme, indirectly affecting Pax-2 expression by modulating the acetylation status of transcription factors involved in Pax-2 regulation. Chrysin inhibits cAMP phosphodiesterase, leading to PKA activation, which in turn influences Pax-2 expression. Moreover, Zebularine is a DNA demethylating agent that indirectly activates Pax-2 by promoting the demethylation of regulatory regions within the Pax-2 gene locus, enhancing its transcription and expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid is a derivative of vitamin A that can activate retinoic acid receptors (RARs). Activation of RARs can lead to downstream signaling events that enhance Pax-2 expression and activity. Specifically, RARs can directly bind to regulatory regions of the Pax-2 gene and promote its transcription. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cyclic AMP (cAMP) levels in cells. Elevated cAMP can activate protein kinase A (PKA), which can subsequently influence Pax-2 expression through PKA-mediated signaling pathways and transcriptional regulation. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
I-BET151 is a bromodomain inhibitor that targets proteins like BRD4, which play a role in transcriptional regulation. Inhibition of BRD4 can indirectly impact Pax-2 by affecting chromatin accessibility and transcriptional regulation at the Pax-2 gene locus. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $30.00 $115.00 $900.00 | 136 | |
DMSO is a solvent that can be used to deliver various chemicals and compounds into cells. It can indirectly activate Pax-2 by facilitating the intracellular delivery of specific activators or modulators of Pax-2-related pathways. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P is a bioactive lipid that can activate S1P receptors. S1P receptor activation can influence Pax-2 expression by affecting signaling events related to cell differentiation and development processes where Pax-2 plays a role. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $325.00 $632.00 $1428.00 $2450.00 $400.00 | 32 | |
Calcitriol is the active form of vitamin D and can activate vitamin D receptors (VDRs). VDR activation can modulate Pax-2 expression by binding to its regulatory regions and promoting transcription, particularly in renal cells where Pax-2 is highly expressed. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide, a form of vitamin B3, can activate the SIRT1 enzyme, which is involved in deacetylating proteins. Activation of SIRT1 can indirectly influence Pax-2 expression by modulating the acetylation status of transcription factors or coactivators involved in Pax-2 regulation. | ||||||
A-485 | 1889279-16-6 | sc-507493 | 5 mg | $275.00 | ||
A-485 is a selective inhibitor of histone deacetylases (HDACs). Inhibition of HDACs can indirectly impact Pax-2 expression by altering the acetylation status of histones and transcription factors that regulate Pax-2 gene transcription. | ||||||
Ginkgolide B | 15291-77-7 | sc-201037B sc-201037 sc-201037C sc-201037A | 5 mg 10 mg 25 mg 50 mg | $45.00 $63.00 $112.00 $197.00 | 8 | |
Ginkgolide B is a natural product that can activate the PKA pathway by inhibiting cAMP phosphodiesterase. PKA activation can indirectly modulate Pax-2 expression through PKA-mediated signaling pathways and transcriptional regulation. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 is a bromodomain inhibitor that targets proteins like BRD4, which play a role in transcriptional regulation. Inhibition of BRD4 can indirectly impact Pax-2 by affecting chromatin accessibility and transcriptional regulation at the Pax-2 gene locus. | ||||||