PAT1 Activators
PAT1 activators comprise a category of chemical entities that have the capability to modulate the activity of the protein PAT1, also known as Proton-Assisted Amino Acid Transporter 1. PAT1 is an integral membrane protein that functions as an amino acid transporter, facilitating the symport of protons and amino acids across the cellular membrane. This protein is crucial for maintaining amino acid homeostasis within cells and is involved in sensing amino acid availability, thereby influencing various cellular pathways, including nutrient signaling and metabolic regulation.
Activators of PAT1 function by either directly interacting with the transporter, enhancing its amino acid transport efficiency, or by indirectly affecting its expression levels, localization, or turnover rate. Direct activators might bind to specific domains on PAT1, eliciting a conformational alteration that increases its affinity for amino acids or its transport capacity. This could involve the stabilization of the protein in a particular state that favors the uptake of amino acids into the cell. On the other hand, indirect activators could operate through modulating the signaling pathways that regulate the expression and activity of PAT1. Such activators could influence the transcriptional machinery to upregulate the synthesis of PAT1, alter the lipid environment of the membrane to enhance PAT1 function, or affect the post-translational modifications that govern the transporter's stability and turnover.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, which increases intracellular cAMP levels leading to the activation of PKA. PKA activation can indirectly influence PAT1 by modulating RNA decay, a process where PAT1 plays a crucial role. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin activates the PI3K/AKT pathway, which has been associated with mRNA translation and decay. The activation of this pathway can indirectly influence the function of PAT1, which is a key player in mRNA decay. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid activates the RAR pathway, which regulates gene expression at the transcriptional level. This could indirectly affect PAT1, which is involved in mRNA decay and localization, by altering the pool of mRNAs available for PAT1-mediated processes. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone activates the glucocorticoid receptor (GR) pathway, which influences gene expression and protein synthesis. This could indirectly influence PAT1, which is involved in mRNA decay and localization. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. It increases acetylation of histones, which can alter gene transcription and indirectly influence the function of PAT1 by modifying the overall mRNA pool in the cell. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can inhibit the NF-κB signaling pathway, which plays a role in gene expression and cellular stress responses. This could indirectly influence PAT1, which is involved in mRNA decay and localization. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin can cause DNA damage, leading to activation of the ATM/ATR pathway. This pathway can indirectly influence PAT1 by modulating the cellular response to DNA damage, which includes changes in mRNA decay. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor. It can influence gene transcription by altering histone acetylation and thus can indirectly influence the function of PAT1 by modifying the overall mRNA pool in the cell. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a central regulator of cell growth and proliferation. This inhibition can influence the processes of mRNA translation and decay, indirectly affecting PAT1. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
H2O2 can induce oxidative stress, which can lead to changes in gene expression and protein synthesis. This can indirectly influence PAT1, which is involved in mRNA decay and localization. | ||||||