PARS2 Activators
PARS2 activators comprise molecules that indirectly enhance the activity of PARS2 through pathways that affect mitochondrial biogenesis, function, or the cellular stress response. These activators do not bind directly to PARS2; instead, they influence cellular processes that may result in the upregulation or increased demand for PARS2 function. For example, SIRT1 activators such as resveratrol and pterostilbene lead to the deacetylation and activation of PGC-1α, a master regulator of mitochondrial biogenesis. Increased mitochondrial content can subsequently demand higher PARS2 activity for mitochondrial DNA synthesis and maintenance. Molecules like NADH and Coenzyme Q10 are fundamental components of the mitochondrial electron transport chain that can support ATP production, thereby fostering an energetic environment that could upregulate PARS2 activity to meet the cellular energy requirements.
On the other hand, sulforaphane and EGCG, which activate Nrf2, initiate cascades that bolster mitochondrial biogenesis and bolster the cellular antioxidant defenses. These pathways are intricately linked to mitochondrial function and integrity, which is where PARS2 comes into play, being essential for mitochondrial DNA repair and replication. The elevation of mitochondrial function and biogenesis is associated with a rise in mitochondrial DNA content, which would naturally enhance the requirement for PARS2 activity. Additionally, mitochondrial-targeted antioxidants like MitoQ protect against oxidative damage and could sustain the functionality of PARS2 by maintaining mitochondrial DNA integrity. The collective role of these activators, therefore, lies in establishing a cellular milieu that supports and necessitates increased PARS2 activity without directly interacting with the protein or its immediate substrates.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, an NAD+-dependent deacetylase, which promotes mitochondrial biogenesis through PGC-1α deacetylation. PARS2, being mitochondrial, can be modulated as SIRT1 enhances mitochondrial function and biogenesis, potentially leading to an increase in PARS2 activity as part of the mitochondrial response. | ||||||
NADH disodium salt | 606-68-8 | sc-205762 sc-205762A | 500 mg 1 g | $91.00 $127.00 | 3 | |
NADH acts as a substrate for complex I in the mitochondrial electron transport chain, supporting ATP production. Enhanced ATP levels can facilitate the function of PARS2, which requires energy to synthesize poly (ADP-ribose) and could be upregulated with increased mitochondrial energy status. | ||||||
Mito-Q | 444890-41-9 | sc-507441 | 5 mg | $290.00 | ||
MitoQ is a mitochondria-targeted antioxidant that can reduce oxidative stress within mitochondria. By protecting mitochondrial DNA from oxidative damage, MitoQ may sustain PARS2 function, as PARS2 is involved in mitochondrial DNA repair and synthesis. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $31.00 $46.00 $122.00 $204.00 | 5 | |
Bezafibrate is a PPAR agonist that can stimulate mitochondrial biogenesis indirectly through PPAR pathways, which may lead to increased demand for mitochondrial DNA replication and repair, potentially enhancing PARS2 activity as part of this upregulation. | ||||||
L-Leucine | 61-90-5 | sc-364173 sc-364173A | 25 g 100 g | $21.00 $62.00 | ||
Leucine can activate mTOR signaling, which is known to be involved in mitochondrial biogenesis and function. An increase in mitochondrial content and function could indirectly enhance PARS2 activity due to the higher demand for mitochondrial DNA synthesis and maintenance where PARS2 plays a role. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG can induce the expression of genes related to mitochondrial biogenesis and function through activation of the Nrf2 pathway, which may lead to an increase in PARS2 activity as mitochondrial biogenesis and antioxidant responses are enhanced. | ||||||
Pterostilbene, Pterocarpus marsupium | 537-42-8 | sc-203223 sc-203223A | 10 mg 100 mg | $211.00 $1196.00 | ||
Pterostilbene, similar to resveratrol, is believed to activate SIRT1 and could thereby promote mitochondrial function and biogenesis, potentially enhancing PARS2 activity as part of the cellular response to increased mitochondrial biogenesis. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates Nrf2, leading to upregulation of antioxidant response element (ARE)-driven genes, which may include genes related to mitochondrial integrity and biogenesis. Through this pathway, PARS2 could be indirectly modulated as part of the broader cellular effort to maintain mitochondrial function in the face of oxidative stress. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Alpha-lipoic acid is involved in mitochondrial bioenergetic processes and has been shown to induce mitochondrial biogenesis. Its role in improving mitochondrial function may thus increase the need for PARS2's activity in mitochondrial DNA synthesis and repair. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
Coenzyme Q10 is integral to the mitochondrial electron transport chain and supports mitochondrial ATP synthesis. By optimizing mitochondrial function, it may indirectly increase the activity of PARS2, which is involved in the mitochondrial response to synthesis and stress. | ||||||