PARP-8 Activators
PARP-8 Activators are a specific class of chemicals that directly or indirectly increase the functional activity of PARP-8, a DNA repair enzyme. These activators work primarily by inducing DNA damage or blocking DNA repair mechanisms, enhancing the recruitment and activity of PARP-8 at DNA damage sites. For instance, Olaparib and Rucaparib, which are PARP inhibitors, can enhance the functional activity of PARP-8 by blocking other PARPs, thereby increasing the recruitment of PARP-8 to DNA damage sites. Similarly, Topotecan, Etoposide, and Camptothecinand Bleomycin, Doxorubicin, and Zeocin, which all induce DNA double-strand breaks, can activate PARP-8 by causing DNA damage, thereby enhancing its recruitment and activity at DNA damage sites.
Moreover, chemicals like Cisplatin and MMS, which form DNA adducts or alkylate DNA, respectively, induce DNA damage that can activate PARP-8, enhancing its recruitment and activity at the sites of DNA damage. Hydroxyurea and Aphidicolin induce DNA replication stress, which can also activate PARP-8. The increase in DNA damage or replication stress caused by these chemicals enhances the recruitment and functional activity of PARP-8 at DNA damage sites, thereby providing diverse mechanisms for the functional activation of PARP-8.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Topotecan | 123948-87-8 | sc-338718 | 100 mg | $571.00 | ||
Topotecan is a topoisomerase I inhibitor that induces DNA damage. PARP-8 can be activated by DNA damage, enhancing its recruitment and activity at DNA damage sites. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide is a topoisomerase II inhibitor that induces DNA damage. As PARP-8 is a DNA repair enzyme, this can enhance its functional activity by increasing recruitment to DNA damage sites. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $270.00 | 5 | |
Bleomycin induces DNA double-strand breaks. PARP-8 can be activated by such DNA damage, enhancing its recruitment and activity at DNA damage sites. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin intercalates into DNA and induces DNA damage. As PARP-8 is a DNA repair enzyme, this can enhance its functional activity by increasing recruitment to DNA damage sites. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin forms DNA adducts leading to DNA damage. PARP-8 can be activated by such DNA damage, enhancing its recruitment and activity at DNA damage sites. | ||||||
Methyl methanesulfonate | 66-27-3 | sc-250376 sc-250376A | 5 g 25 g | $55.00 $130.00 | 2 | |
MMS is a DNA alkylating agent that induces DNA damage. As PARP-8 is a DNA repair enzyme, this can enhance its functional activity by increasing recruitment to DNA damage sites. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, inducing DNA replication stress and damage. PARP-8 can be activated by such DNA damage, enhancing its recruitment and activity at DNA damage sites. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Aphidicolin is a DNA polymerase α inhibitor that induces DNA replication stress. PARP-8 can be activated by this stress, enhancing its recruitment and activity at DNA damage sites. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin is a topoisomerase I inhibitor that induces DNA damage. PARP-8 can be activated by such DNA damage, enhancing its recruitment and activity at DNA damage sites. | ||||||