PARP-2 Activators
PARP-2 (Poly ADP-ribose polymerase 2) activators represent a chemical class of compounds that play a pivotal role in modulating the activity of the PARP-2 enzyme, an essential component of the cellular machinery involved in DNA repair and maintenance processes. These activators are characterized by their ability to stimulate the enzymatic activity of PARP-2, primarily by promoting the poly-ADP ribosylation of target proteins. This chemical class encompasses a diverse range of molecules, including natural compounds found in foods and beverages, as well as synthetic compounds specifically designed for research purposes.
Many PARP-2 activators are from dietary sources, such as resveratrol, quercetin, and epigallocatechin gallate (EGCG). These phytochemicals are often classified as polyphenols and are abundant in fruits, vegetables, and beverages like red wine and green tea. Additionally, certain vitamins like nicotinamide, a form of vitamin B3, are vital cofactors for PARP-2 activation. These activators serve as coenzymes, providing the necessary substrates, like nicotinamide adenine dinucleotide (NAD+), for PARP-2 to catalyze the addition of poly-ADP ribose chains to target proteins, which is crucial for orchestrating DNA repair processes within the cell. Understanding the structural and chemical properties of PARP-2 activators is fundamental in unraveling the intricate mechanisms governing DNA repair and cellular responses to DNA damage.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide is a form of vitamin B3 that has been reported to activate PARP-It is involved in the NAD+ (nicotinamide adenine dinucleotide) pathway, which is crucial for cellular energy production and DNA repair. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a natural compound found in grapes and red wine. It has been suggested to activate PARP-2, among other cellular pathways associated with health benefits. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid found in various fruits and vegetables. It has been proposed to have PARP-2 activating properties, potentially contributing to its antioxidant and anti-inflammatory effects. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine, a well-known stimulant found in coffee and tea, has been studied for its potential role in DNA repair through PARP-2 activation. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol is another flavonoid found in plants. It has been investigated for its potential to activate PARP-2 and thereby enhance DNA repair processes. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone found in soy products. It has been investigated for its potential role in various cellular processes, including DNA repair through PARP-2 activation. | ||||||