PAI-3 Activators
The vast and intricate cellular environment involves a diverse array of molecules, including some that can potentially activate the protein PAI-3 (SERPINA5). Among these, Forskolin stands out, capable of increasing cAMP levels and subsequently stimulating PKA, influencing pathways associated with PAI-3. Similarly, Retinoic acid modifies gene transcription by affecting nuclear receptors, shaping the PAI-3 functional landscape. Sodium butyrate, known for its HDAC inhibitory capabilities, can foster conditions favoring heightened PAI-3 transcriptional activity.
The play of chemicals continues with Epidermal growth factor (EGF) sparking signaling cascades upon receptor activation, events that might intertwine with PAI-3's pathways. The role of Lithium chloride as an inhibitor of GSK-3β and the resulting pathway modifications, introduces another angle to the PAI-3 activation discourse. Then come MG-132 and Rapamycin, molecules altering protein levels and mTOR signaling respectively, redefining the PAI-3's functional landscape. Other significant players, such as Staurosporine, Ionomycin, Dexamethasone, PMA, and Roscovitine, expand the understanding by engaging with kinases, calcium signaling, gene transcription, and cell cycle dynamics. Together, these chemicals offer a perspective on the potential influencers of PAI-3 in cellular systems.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Elevates cAMP levels which can activate PKA, potentially influencing PAI-3-associated pathways. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Affects nuclear receptors to modify gene transcription patterns which can impact PAI-3 functionality. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As an HDAC inhibitor, it can modulate PAI-3 expression through enhanced transcriptional activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium inhibits GSK-3β, thereby modifying pathways potentially influencing PAI-3. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
By inhibiting the proteasome, MG-132 can elevate protein levels that regulate or are associated with PAI-3. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibition of mTOR signaling by Rapamycin can modify cellular processes potentially impacting PAI-3. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
This kinase inhibitor modulates phosphorylation states of proteins, potentially impacting PAI-3 indirectly. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin's elevation of intracellular calcium levels can activate signaling routes potentially influencing PAI-3. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
A glucocorticoid that can modulate gene transcription, potentially influencing PAI-3 function or expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activating PKC, PMA affects multiple cellular substrates and pathways, potentially impacting PAI-3. | ||||||