PAF acetylhydrolase 2 Activators
PAF acetylhydrolase 2 Activators represent a theoretical class of compounds that could enhance the activity of PAF acetylhydrolase 2 by influencing the production and turnover of PAF within cellular systems. These compounds may either increase the availability of substrates necessary for the synthesis of PAF, thereby providing more material for PAF acetylhydrolase 2 to act upon, or they may alter cellular signaling pathways to upregulate the enzyme's activity indirectly. For instance, compounds like Phosphatidylcholine and CDP-Choline are integral to the synthesis of PAF. By increasing the levels of these molecules, the cellular conditions may become more favorable for PAF synthesis, which could, in turn, stimulate PAF acetylhydrolase 2 to maintain homeostasis by catabolizing the excess PAF.
Moreover, signaling molecules such as Sphingosine-1-phosphate and Arachidonic Acid, which are involved in complex lipid signaling pathways, can have cascading effects on the regulation of enzyme activities, including PAF acetylhydrolase 2. Although these effects are often indirect, they are a vital part of the regulatory mechanisms that maintain lipid mediator balance within cells. Forskolin's action on cAMP levels is another example of how cellular signaling can be leveraged to modulate enzyme activity, leading to an overall increase in the functional activity of PAF acetylhydrolase 2. These activators require further research to confirm their effects and elucidate the precise mechanisms by which they might enhance the activity of PAF acetylhydrolase 2.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-α-Lecithin, Egg Yolk, Highly Purified | 8002-43-5 | sc-203096 | 250 mg | $135.00 | ||
Phosphatidylcholine is a precursor molecule for the synthesis of platelet-activating factor (PAF). Since PAF acetylhydrolase 2 functions to hydrolyze PAF, an increase in phosphatidylcholine levels can lead to increased PAF production, which in turn may provide more substrate for PAF acetylhydrolase 2, thereby potentially enhancing its functional activity. | ||||||
Ginkgolide B | 15291-77-7 | sc-201037B sc-201037 sc-201037C sc-201037A | 5 mg 10 mg 25 mg 50 mg | $46.00 $64.00 $114.00 $201.00 | 8 | |
Ginkgolide B, a terpenoid found in Ginkgo biloba, is a known PAF receptor antagonist. While it does not directly activate PAF acetylhydrolase 2, by blocking PAF receptors, it may lead to elevated PAF levels in the bloodstream, which could indirectly increase the activity of PAF acetylhydrolase 2 as it works to hydrolyze excess PAF. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcium ionophore A23187 elevates intracellular calcium levels, which can stimulate the enzymatic activity of various enzymes, including PAF acetylhydrolase 2, as calcium is a cofactor that can modulate enzyme activity. | ||||||
Edelfosine | 70641-51-9 | sc-507459 | 5 mg | $216.00 | ||
Edelfosine is an alkyl-lysophospholipid analog that can act as a PAF analog. Its presence may competitively enhance the activity of PAF acetylhydrolase 2, as the enzyme works to maintain PAF homeostasis. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate is involved in signaling pathways that regulate cellular processes, including those that may influence lipid metabolism and the activities of enzymes like PAF acetylhydrolase 2. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which can enhance the activity of various enzymes, potentially including PAF acetylhydrolase 2, by signaling cascades that involve cAMP-dependent protein kinase (PKA). | ||||||
D609 | 83373-60-8 | sc-201403 sc-201403A | 5 mg 25 mg | $189.00 $575.00 | 7 | |
Tricyclodecan-9-yl-xanthogenate (D609) inhibits the synthesis of phosphatidylcholine-derived PAF. By altering the balance of PAF synthesis and degradation, D609 could lead to a compensatory increase in PAF acetylhydrolase 2 activity. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic acid can be converted into various eicosanoids, some of which might influence the activity of PAF acetylhydrolase 2 indirectly through cellular signaling pathways. | ||||||
PAF C-16 | 74389-68-7 | sc-201009 sc-201009A | 5 mg 25 mg | $131.00 $300.00 | 10 | |
PAF itself, when supplied exogenously, could enhance the activity of PAF acetylhydrolase 2 by increasing the enzyme's substrate availability. | ||||||