PACSIN3 Inhibitors
PACSIN3 inhibitors belong to a distinctive chemical class designed to target the protein PACSIN3, an acronym for protein kinase C and casein kinase substrate in neurons 3. PACSIN3 is a member of the PACSIN (Protein Kinase C and Casein Kinase Substrate in Neurons) family of proteins, which play crucial roles in cellular processes related to endocytosis and membrane dynamics. The development of PACSIN3 inhibitors stems from the recognition of PACSIN3's involvement in the regulation of vesicle trafficking and its significance in cellular homeostasis.
PACSIN3 inhibitors are designed to interact specifically with the active site or allosteric regions of PACSIN3, impeding its normal function. These inhibitors are meticulously crafted to ensure high selectivity and potency in inhibiting PACSIN3 activity. Researchers employ a variety of molecular design strategies, such as structure-based drug design and high-throughput screening, to identify and optimize compounds with the ability to selectively modulate PACSIN3. Understanding the structural nuances of PACSIN3 and its intricate involvement in cellular processes is pivotal in the rational design of these inhibitors.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydroxy-Dynasore | 1256493-34-1 | sc-364678 | 10 mg | $255.00 | ||
This compound inhibits dynamin, thereby potentially affecting endocytosis where PACSIN3 is involved. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
Cdc42 inhibitor, which could alter cytoskeletal dynamics that PACSIN3 is associated with. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
Inhibits Arp2/3 complex, which can affect actin polymerization and potentially PACSIN3 function. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
Inhibits formin, which is involved in actin assembly and could indirectly affect PACSIN3. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Inhibits ROCK, potentially impacting actin cytoskeleton and consequently PACSIN3 activity. | ||||||
IPA 3 | 42521-82-4 | sc-204016 sc-204016A | 5 mg 50 mg | $94.00 $458.00 | 6 | |
PAK inhibitor, which may alter actin dynamics and indirectly influence PACSIN3. | ||||||
Latrunculin B | 76343-94-7 | sc-203318 | 1 mg | $240.00 | 29 | |
Binds to actin monomers and can impact actin polymerization, indirectly affecting PACSIN3. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Inhibits myosin II and could thereby influence cellular processes related to PACSIN3. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
PI3 kinase inhibitor, which might affect endocytic pathways where PACSIN3 is involved. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Disrupts actin filaments, potentially affecting cellular processes related to PACSIN3. | ||||||