p60TRP Inhibitors
The functional inhibition of p60TRP can be achieved through various chemical compounds that target specific cellular processes and pathways. Disruption of phosphorylation-dependent signaling by kinase inhibitors can alter the trafficking and sorting activities of p60TRP, as its function is influenced by the phosphorylation status of associated proteins. Similarly, the inhibition of protein kinase C delta by certain compounds modifies the signaling pathway that p60TRP may regulate in the sorting of membrane proteins. This pathway-specific inhibition is critical in maintaining the sorting balance, and interference can reduce the functional activity of p60TRP. Additionally, the inhibition of tyrosine kinases can affect the endocytic sorting of p60TRP by changing the tyrosine phosphorylation landscape, which is essential for the operation of sorting proteins. The action of GTPase inhibitors further impacts the endocytic pathways that p60TRP is involved in, by interfering with the endocytosis mediated by proteins such as dynamin.
On the other hand, the disruption of cellular structures and the trafficking machinery also plays a significant role in the inhibition of p60TRP function. Compounds that perturb Golgi function or vesicle budding from the Golgi can impact the post-Golgi trafficking and sorting of p60TRP, as it could be dependent on the integrity of the Golgi apparatus for proper localization and function. Cytoskeletal disruptors, such as those targeting actin filaments or microtubules, can also induce significant alterations in the trafficking dynamics of p60TRP. By destabilizing the cytoskeletal network, these agents can impair the directed transport of vesicles, consequently affecting the distribution and function of p60TRP in various cellular compartments. Moreover, the use of chemicals that selectively interrupt the function of motor proteins can lead to a similar outcome, as these proteins are responsible for the propulsive forces that drive vesicle and organelle transport along the cytoskeleton.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
This kinase inhibitor interferes with the phosphorylation of downstream proteins, potentially leading to altered trafficking and sorting of p60TRP due to impaired phosphorylation-dependent signaling. | ||||||
Rottlerin | 82-08-6 | sc-3550 sc-3550B sc-3550A sc-3550C sc-3550D sc-3550E | 10 mg 25 mg 50 mg 1 g 5 g 20 g | $82.00 $163.00 $296.00 $2050.00 $5110.00 $16330.00 | 51 | |
This compound is known to inhibit Protein kinase C delta (PKCδ), which could impact the sorting functions of p60TRP by modifying the PKCδ-dependent signaling pathway that may regulate the trafficking of membrane proteins. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
As a tyrosine kinase inhibitor, it could affect the endocytic sorting of p60TRP by altering tyrosine phosphorylation status, which is critical for the function and regulation of sorting proteins within the cell. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
This GTPase inhibitor disrupts dynamin-mediated endocytosis, which could indirectly reduce the functional activity of p60TRP by interfering with the endocytic pathways that it is involved in. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
This ionophore disrupts Golgi function, potentially affecting the post-Golgi trafficking and sorting of p60TRP as it may regulate the transport of proteins from the Golgi to the plasma membrane. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
An inhibitor of ADP-ribosylation factor (ARF), which affects vesicle budding from the Golgi, potentially impacting the sorting and trafficking functions of p60TRP by disrupting the ARF-dependent pathways. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
This cationic amphiphilic compound disrupts clathrin-mediated endocytosis, potentially reducing the functional activity of p60TRP by preventing the proper internalization and recycling of proteins that p60TRP is associated with. | ||||||
Methyl-β-cyclodextrin | 128446-36-6 | sc-215379A sc-215379 sc-215379C sc-215379B | 100 mg 1 g 10 g 5 g | $25.00 $65.00 $170.00 $110.00 | 19 | |
By depleting cholesterol from the plasma membrane, this compound can disrupt lipid rafts and potentially affect the localization and function of p60TRP, which is critical for the sorting and trafficking of associated receptors. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
An agent that depolymerizes microtubules, potentially affecting the intracellular distribution and trafficking of p60TRP as it may require intact microtubules for transport of proteins within the cell. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A phosphoinositide 3-kinase inhibitor that could affect the sorting and trafficking functions of p60TRP by disrupting the PI3K-dependent signaling pathways that regulate membrane trafficking. | ||||||